INT230516

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Context Info
Confidence 0.15
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.64
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il2) extracellular region (Il2)
Anatomy Link Frequency
T-cell 8
lymphocyte 2
Il2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 6 96.56 Very High Very High Very High
Thoracotomy 8 91.00 High High
cva 13 87.48 High High
vagus nerve 1 76.32 Quite High
fibrosis 16 67.96 Quite High
Clonidine 9 67.28 Quite High
Inflammatory mediators 1 60.84 Quite High
Inflammation 39 59.28 Quite High
cytokine 19 52.24 Quite High
ischemia 109 50.00 Quite Low
Disease Link Frequency Relevance Heat
Injury 37 94.00 High High
Infection 78 92.40 High High
Intracranial Hypertension 1 87.48 High High
Sleep Disorders 75 85.56 High High
Sepsis 13 83.12 Quite High
Pulmonary Fibrosis 4 67.96 Quite High
Reperfusion Injury 389 67.84 Quite High
Lung Injury 24 66.24 Quite High
INFLAMMATION 43 60.44 Quite High
Apoptosis 9 58.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, mitogen-induced lymphocyte proliferation, IL-2, and IL-4 secretion were not depressed.
Neg (not) Negative_regulation (depressed) of Localization (secretion) of IL-2 in lymphocyte
1) Confidence 0.15 Published 2010 Journal Crit Care Section Body Doc Link PMC2887136 Disease Relevance 0.65 Pain Relevance 0.36
The immunosuppressive effect of surgery may be due to reduced T-cell proliferation and reduced secretion of interleukin-2 (IL-2), IL-4, and gamma interferon by T-lymphocytes, which may be the effect of inhibitory factors secreted by mononuclear phagocytic cells as a result of injury [60].
Negative_regulation (reduced) of Localization (secretion) of IL-2 in T-cell associated with injury
2) Confidence 0.07 Published 2008 Journal Respir Res Section Body Doc Link PMC2335107 Disease Relevance 0.50 Pain Relevance 0.11
The immunosuppressive effect of surgery may be due to reduced T-cell proliferation and reduced secretion of interleukin-2 (IL-2), IL-4, and gamma interferon by T-lymphocytes, which may be the effect of inhibitory factors secreted by mononuclear phagocytic cells as a result of injury [60].
Negative_regulation (reduced) of Localization (secretion) of IL-2 in T-cell associated with injury
3) Confidence 0.07 Published 2008 Journal Respir Res Section Body Doc Link PMC2335107 Disease Relevance 0.50 Pain Relevance 0.11
The immunosuppressive effect of surgery may be due to reduced T-cell proliferation and reduced secretion of interleukin-2 (IL-2), IL-4, and gamma interferon by T-lymphocytes, which may be the effect of inhibitory factors secreted by mononuclear phagocytic cells as a result of injury [60].
Negative_regulation (reduced) of Localization (secretion) of interleukin-2 in T-cell associated with injury
4) Confidence 0.05 Published 2008 Journal Respir Res Section Body Doc Link PMC2335107 Disease Relevance 0.49 Pain Relevance 0.11
The immunosuppressive effect of surgery may be due to reduced T-cell proliferation and reduced secretion of interleukin-2 (IL-2), IL-4, and gamma interferon by T-lymphocytes, which may be the effect of inhibitory factors secreted by mononuclear phagocytic cells as a result of injury [60].
Negative_regulation (proliferation) of Localization (secretion) of interleukin-2 in T-cell associated with injury
5) Confidence 0.05 Published 2008 Journal Respir Res Section Body Doc Link PMC2335107 Disease Relevance 0.50 Pain Relevance 0.11

General Comments

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