INT230517

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Context Info
Confidence 0.15
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.38
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
muscle fiber 1
lungs 1
Myo1f (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 60 92.00 High High
cytokine 3 91.00 High High
ischemia 27 64.56 Quite High
fibrosis 4 63.60 Quite High
Thoracotomy 2 17.76 Low Low
metalloproteinase 15 5.00 Very Low Very Low Very Low
Inflammation 9 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 1 100.00 Very High Very High Very High
Apoptosis 11 99.84 Very High Very High Very High
Reperfusion Injury 97 99.72 Very High Very High Very High
Frailty 5 97.56 Very High Very High Very High
Aging 38 92.48 High High
Adhesions 1 85.20 High High
Injury 9 65.16 Quite High
Cv Unclassified Under Development 25 64.56 Quite High
Pulmonary Fibrosis 1 64.00 Quite High
Lung Injury 6 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Paradoxically, this increased Akt phosphorylation is associated with lower Akt kinase activity, diminished response to insulin, higher levels of myocyte apoptosis, lower abundance of contractile proteins myosin and actin, and a smaller muscle fiber cross-sectional area (atrophy).
Localization (abundance) of myosin in muscle fiber associated with frailty and apoptosis
1) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.46 Pain Relevance 0.30
Myosin, heat shock proteins and type V collagen, which is released after LIRI in BALf comparable to the level observed in allografted lungs, have been shown to be capable of inducing a T-helper-cell reaction within days after reperfusion [54,55].
Localization (released) of Myosin in lungs associated with reperfusion injury and shock
2) Confidence 0.02 Published 2008 Journal Respir Res Section Body Doc Link PMC2335107 Disease Relevance 0.91 Pain Relevance 0.14

General Comments

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