INT230519

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Context Info
Confidence 0.60
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.79
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cd5)
Anatomy Link Frequency
helper T-lymphocytes 3
B-cell 2
Cd5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 49 81.04 Quite High
cytokine 8 59.12 Quite High
ischemia 81 50.00 Quite Low
methotrexate 4 36.28 Quite Low
corticosteroid 6 32.32 Quite Low
Demyelination 4 11.92 Low Low
metalloproteinase 45 5.00 Very Low Very Low Very Low
fibrosis 12 5.00 Very Low Very Low Very Low
cva 9 5.00 Very Low Very Low Very Low
Thoracotomy 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypersensitivity 15 99.46 Very High Very High Very High
Apoptosis 5 98.28 Very High Very High Very High
Necrosis 2 94.88 High High
Cancer 2 94.52 High High
INFLAMMATION 49 81.04 Quite High
Multiple Sclerosis 2 72.88 Quite High
Disease 8 69.88 Quite High
Uveitis 2 68.32 Quite High
Idiopathic Thrombocytopenic Purpura 2 65.52 Quite High
Chronic Inflammatory Demyelinating Polyradiculoneuropathy 66 50.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cells were identified as follows: Lymphocytes low FSC, low SSC, no autofluorescence, and expressing either CD45RA+ (B-lymphocytes), CD5+ (T-lymphocytes), CD5+CD4+ (helper T-lymphocytes), and CD5+CD8+ (cytotoxic T-lymphocytes); neutrophils low FSC, intermediate SSC and HIS48+; macrophages as high SSC and FSC and autofluorescent [34].
Gene_expression (expressing) of CD5 in helper T-lymphocytes associated with hypersensitivity
1) Confidence 0.60 Published 2008 Journal Respir Res Section Body Doc Link PMC2335107 Disease Relevance 0.38 Pain Relevance 0
Cells were identified as follows: Lymphocytes low FSC, low SSC, no autofluorescence, and expressing either CD45RA+ (B-lymphocytes), CD5+ (T-lymphocytes), CD5+CD4+ (helper T-lymphocytes), and CD5+CD8+ (cytotoxic T-lymphocytes); neutrophils low FSC, intermediate SSC and HIS48+; macrophages as high SSC and FSC and autofluorescent [34].
Gene_expression (expressing) of CD5 in helper T-lymphocytes associated with hypersensitivity
2) Confidence 0.60 Published 2008 Journal Respir Res Section Body Doc Link PMC2335107 Disease Relevance 0.38 Pain Relevance 0
Cells were identified as follows: Lymphocytes low FSC, low SSC, no autofluorescence, and expressing either CD45RA+ (B-lymphocytes), CD5+ (T-lymphocytes), CD5+CD4+ (helper T-lymphocytes), and CD5+CD8+ (cytotoxic T-lymphocytes); neutrophils low FSC, intermediate SSC and HIS48+; macrophages as high SSC and FSC and autofluorescent [34].
Gene_expression (expressing) of CD5 in helper T-lymphocytes associated with hypersensitivity
3) Confidence 0.52 Published 2008 Journal Respir Res Section Body Doc Link PMC2335107 Disease Relevance 0.38 Pain Relevance 0
,34 induction of B-cell apoptosis,35 downregulation of specific auto-reactive B-cells and regulation of B-cell subsets expressing CD5,36 thereby suppressing the auto-antibody producing CD20+ B1 cells.
Gene_expression (expressing) of CD5 in B-cell associated with apoptosis
4) Confidence 0.34 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2846143 Disease Relevance 0.82 Pain Relevance 0.10
,34 induction of B-cell apoptosis,35 downregulation of specific auto-reactive B-cells and regulation of B-cell subsets expressing CD5,36 thereby suppressing the auto-antibody producing CD20+ B1 cells.
Gene_expression (expressing) of CD5 in B-cell associated with apoptosis
5) Confidence 0.29 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2846143 Disease Relevance 0.82 Pain Relevance 0.10

General Comments

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