INT230520

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.71
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cd5)
Anatomy Link Frequency
lung 2
B cells 1
Cd5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 12 97.04 Very High Very High Very High
depression 2 96.48 Very High Very High Very High
cytokine 10 74.52 Quite High
ischemia 81 50.00 Quite Low
Inflammation 33 50.00 Quite Low
Thoracotomy 6 48.24 Quite Low
metalloproteinase 45 5.00 Very Low Very Low Very Low
cva 9 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reperfusion Injury 291 99.20 Very High Very High Very High
Pulmonary Fibrosis 3 97.24 Very High Very High Very High
Depression 2 96.48 Very High Very High Very High
Viral Infection 1 94.44 High High
Chronic Fatigue Syndrome 65 91.92 High High
Fatigue 22 89.32 High High
Shock 3 84.24 Quite High
Adhesions 4 68.72 Quite High
Hypersensitivity 15 50.24 Quite High
Cv Unclassified Under Development 75 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hereafter, cells were washed, centrifuged and surface-stained for 30 minutes at 4°C in the dark with the following primary mouse anti rat antibodies: biotin conjugated CD5 (OX191), phycoerythrin (PE) labelled CD8 (OX82), fluorescein-isothiocyanate (FITC) labelled CD4 (OX382), CD45RA-PE (OX331), and HIS481.
Positive_regulation (conjugated) of CD5
1) Confidence 0.38 Published 2008 Journal Respir Res Section Body Doc Link PMC2335107 Disease Relevance 0.05 Pain Relevance 0
Finally, the elevated levels of CD5+CD4+ and CD5+CD8+ may be explained by their possible role in the pathogenesis of lung fibrosis, which is also supported by the presence of macrophages in the BALf and lung parenchyma of ischemic animals 3, 7, and 90 days after reperfusion, since they are also thought to be important mediators in the regulation of fibroblast function [37,38,57,58].
Positive_regulation (elevated) of CD5 in lung associated with fibrosis and pulmonary fibrosis
2) Confidence 0.36 Published 2008 Journal Respir Res Section Body Doc Link PMC2335107 Disease Relevance 0.50 Pain Relevance 0.09
Finally, the elevated levels of CD5+CD4+ and CD5+CD8+ may be explained by their possible role in the pathogenesis of lung fibrosis, which is also supported by the presence of macrophages in the BALf and lung parenchyma of ischemic animals 3, 7, and 90 days after reperfusion, since they are also thought to be important mediators in the regulation of fibroblast function [37,38,57,58].
Positive_regulation (elevated) of CD5 in lung associated with fibrosis and pulmonary fibrosis
3) Confidence 0.36 Published 2008 Journal Respir Res Section Body Doc Link PMC2335107 Disease Relevance 0.50 Pain Relevance 0.09
Robertson et al. [7] recently reported significantly higher abundance of CD20+/CD5+ B cells, a subset associated with the production of auto-antibodies, in patients with depression.
Positive_regulation (abundance) of CD5 in B cells associated with depression
4) Confidence 0.13 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2569951 Disease Relevance 0.65 Pain Relevance 0.05

General Comments

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