INT230575

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Context Info
Confidence 0.28
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.57
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 2
Trpv3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 26 99.84 Very High Very High Very High
Root ganglion neuron 23 94.80 High High
Pain 13 93.24 High High
alcohol 6 89.08 High High
agonist 21 83.40 Quite High
TRP channel 31 81.52 Quite High
Neuropathic pain 19 51.00 Quite High
Inflammation 17 50.16 Quite High
antagonist 11 50.00 Quite Low
Antinociceptive 6 30.24 Quite Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 28 94.48 High High
Pain 15 93.24 High High
Myelodysplastic Syndromes 1 90.32 High High
Loss Of Sense Of Smell 2 55.68 Quite High
Neuropathic Pain 27 51.00 Quite High
INFLAMMATION 18 50.16 Quite High
Hypersensitivity 34 49.12 Quite Low
Inflammatory Pain 11 5.00 Very Low Very Low Very Low
Nociception 6 5.00 Very Low Very Low Very Low
Injury 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We find that TRPV2 and TRPV3 channels are present in a high proportion of these neurons (94% respond to 2-aminoethyldiphenyl borate), consistent with our immunolabeling experiments and previous in situ hybridization studies.
Negative_regulation (present) of Gene_expression (channels) of TRPV3 in neurons
1) Confidence 0.28 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2346451 Disease Relevance 0.28 Pain Relevance 0.43
Previous reports demonstrated that HC-030031 does not block TRPV1, TRPV3 or TRPV4 activation by capsaicin, 2-APB, and 4?
Negative_regulation (block) of Gene_expression (activation) of TRPV3 associated with qutenza
2) Confidence 0.23 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584039 Disease Relevance 0.28 Pain Relevance 0.30

General Comments

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