INT230576

Context Info Confidence 0.46 First Reported 2008 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 8 Total Number 8 Disease Relevance 0.83 Pain Relevance 2.35

Trpv3 (Rattus norvegicus)

Pain Link Frequency Relevance Heat agonist 111 100.00 qutenza 202 99.84 TRP channel 182 97.28 Calcium channel 6 95.16 Pain 37 92.72 Root ganglion neuron 138 88.48 alcohol 36 85.52 addiction 12 83.00 Potency 32 78.64 nociceptor 3 52.56

Disease Link Frequency Relevance Heat Pain 36 92.72 Myelodysplastic Syndromes 1 89.80 Ganglion Cysts 168 88.16 Confusion 2 66.48 Contact Dermatitis 6 51.20 Neuropathic Pain 40 50.48 INFLAMMATION 27 50.00 Hypersensitivity 34 48.60 Tick Infestations 6 46.40 Nociception 28 32.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

TRPV2 currents were not potentiated by repeated 2-aminoethyldiphenyl borate application, while camphor activated TRPV3 and the channels were sensitized by repeated 2-aminoethyldiphenyl borate applications.

Positive_regulation (activated) of TRPV3

1) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346451 Disease Relevance 0.19 Pain Relevance 0.20

Both aldehydes and their related alcohols (neral, nerol, geranial, and geraniol) weakly activated TRPV1 (Fig. 3B), TRPV3, TRPM8 (Fig.

Positive_regulation (activated) of TRPV3

2) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346451 Disease Relevance 0 Pain Relevance 0.08

The term warming was rarely used over the 30-min time course indicating that IBA (and likely other alkylamides) does not initiate activity in warm-sensitive pathways via TRPV3 or TRPV4 activation.

Positive_regulation (activation) of TRPV3

3) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2831077 Disease Relevance 0.07 Pain Relevance 0.11

Citral is both an activator and inhibitor of TRPV1, TRPV3, TRPM8, and TRPA1, but these opposing actions cannot be attributed to the cis and trans enantiomers.

Positive_regulation (activator) of TRPV3

4) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346451 Disease Relevance 0 Pain Relevance 0.38

Citral activates TRPV1, TRPV3, TRPM8, and TRPA1

Positive_regulation (activates) of TRPV3

5) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346451 Disease Relevance 0.21 Pain Relevance 0.39

Citral initially increased the agonist-evoked responses of TRPV1, TRPV2, and TRPV3 (Fig. 2A, B).

Positive_regulation (increased) of TRPV3 associated with agonist

6) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346451 Disease Relevance 0 Pain Relevance 0.55

Citral significantly increased TRPV1, TRPV3, TRPM8, and TRPA1 (Fig. 1A and B) currents, but not TRPV2 (Fig. 1E), TRPV4, or background currents in nontransfected cells (data not shown).

Neg (not) Positive_regulation (increased) of TRPV3

7) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346451 Disease Relevance 0.14 Pain Relevance 0.37

Previous reports demonstrated that HC-030031 does not block TRPV1, TRPV3 or TRPV4 activation by capsaicin, 2-APB, and 4?

Positive_regulation (activation) of TRPV3 associated with qutenza

8) Confidence 0.25 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584039 Disease Relevance 0.23 Pain Relevance 0.28

General Comments

This test has worked.