INT230576

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Context Info
Confidence 0.46
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 0.83
Pain Relevance 2.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Trpv3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 111 100.00 Very High Very High Very High
qutenza 202 99.84 Very High Very High Very High
TRP channel 182 97.28 Very High Very High Very High
Calcium channel 6 95.16 Very High Very High Very High
Pain 37 92.72 High High
Root ganglion neuron 138 88.48 High High
alcohol 36 85.52 High High
addiction 12 83.00 Quite High
Potency 32 78.64 Quite High
nociceptor 3 52.56 Quite High
Disease Link Frequency Relevance Heat
Pain 36 92.72 High High
Myelodysplastic Syndromes 1 89.80 High High
Ganglion Cysts 168 88.16 High High
Confusion 2 66.48 Quite High
Contact Dermatitis 6 51.20 Quite High
Neuropathic Pain 40 50.48 Quite High
INFLAMMATION 27 50.00 Quite Low
Hypersensitivity 34 48.60 Quite Low
Tick Infestations 6 46.40 Quite Low
Nociception 28 32.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TRPV2 currents were not potentiated by repeated 2-aminoethyldiphenyl borate application, while camphor activated TRPV3 and the channels were sensitized by repeated 2-aminoethyldiphenyl borate applications.
Positive_regulation (activated) of TRPV3
1) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346451 Disease Relevance 0.19 Pain Relevance 0.20
Both aldehydes and their related alcohols (neral, nerol, geranial, and geraniol) weakly activated TRPV1 (Fig. 3B), TRPV3, TRPM8 (Fig.
Positive_regulation (activated) of TRPV3
2) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346451 Disease Relevance 0 Pain Relevance 0.08
The term warming was rarely used over the 30-min time course indicating that IBA (and likely other alkylamides) does not initiate activity in warm-sensitive pathways via TRPV3 or TRPV4 activation.
Positive_regulation (activation) of TRPV3
3) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2831077 Disease Relevance 0.07 Pain Relevance 0.11
Citral is both an activator and inhibitor of TRPV1, TRPV3, TRPM8, and TRPA1, but these opposing actions cannot be attributed to the cis and trans enantiomers.
Positive_regulation (activator) of TRPV3
4) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346451 Disease Relevance 0 Pain Relevance 0.38
Citral activates TRPV1, TRPV3, TRPM8, and TRPA1
Positive_regulation (activates) of TRPV3
5) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346451 Disease Relevance 0.21 Pain Relevance 0.39
Citral initially increased the agonist-evoked responses of TRPV1, TRPV2, and TRPV3 (Fig. 2A, B).
Positive_regulation (increased) of TRPV3 associated with agonist
6) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346451 Disease Relevance 0 Pain Relevance 0.55
Citral significantly increased TRPV1, TRPV3, TRPM8, and TRPA1 (Fig. 1A and B) currents, but not TRPV2 (Fig. 1E), TRPV4, or background currents in nontransfected cells (data not shown).
Neg (not) Positive_regulation (increased) of TRPV3
7) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346451 Disease Relevance 0.14 Pain Relevance 0.37
Previous reports demonstrated that HC-030031 does not block TRPV1, TRPV3 or TRPV4 activation by capsaicin, 2-APB, and 4?
Positive_regulation (activation) of TRPV3 associated with qutenza
8) Confidence 0.25 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584039 Disease Relevance 0.23 Pain Relevance 0.28

General Comments

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