INT230623

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.46
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (SOX10) DNA binding (SOX10) cytoplasm (SOX10)
Anatomy Link Frequency
oligodendrocyte 1
SOX10 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 21 99.32 Very High Very High Very High
nMDA receptor 7 98.76 Very High Very High Very High
agonist 5 98.16 Very High Very High Very High
Glutamate receptor 6 88.60 High High
Neurotransmitter 5 86.24 High High
excitatory amino acid 3 83.60 Quite High
Serotonin 2 74.08 Quite High
gABA 9 70.28 Quite High
Hippocampus 15 67.12 Quite High
Central nervous system 15 23.84 Low Low
Disease Link Frequency Relevance Heat
Toxicity 29 80.32 Quite High
Renal Disease 1 76.64 Quite High
Injury 23 56.00 Quite High
Brain Disease 5 53.28 Quite High
Shellfish Poisoning 11 45.84 Quite Low
Poisoning 23 40.80 Quite Low
Drug Induced Neurotoxicity 8 31.96 Quite Low
Epilepsy 5 26.56 Quite Low
Syndrome 4 25.52 Quite Low
Rheumatoid Arthritis 21 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The downregulation of early (SOX10) and upregulation of late precursor markers PDGF-R [9], [18] and PLP reveals the presence of mature oligodendrocyte cells (Figure 1D).
Negative_regulation (downregulation) of SOX10 in oligodendrocyte
1) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346555 Disease Relevance 0 Pain Relevance 0.11
A synergistic effect of DOM with endogenous glutamate and NMDA receptors agonists, has been demonstrated in vitro and in vivo, which contributes to the excitotoxicity [67,79,80].
Negative_regulation (effect) of DOM associated with glutamate, nmda receptor and agonist
2) Confidence 0.29 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525487 Disease Relevance 0.46 Pain Relevance 0.35

General Comments

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