INT230633

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Context Info
Confidence 0.30
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.40
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (MNX1)
Anatomy Link Frequency
motor neuron 1
MNX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 41 96.68 Very High Very High Very High
Spinal cord 6 83.80 Quite High
Pain 44 75.00 Quite High
Osteoarthritis 89 68.88 Quite High
agonist 11 62.84 Quite High
Central nervous system 7 59.00 Quite High
midbrain 5 51.64 Quite High
Dopamine 9 44.88 Quite Low
Glutamate receptor 1 8.88 Low Low
gABA 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 21 95.50 Very High Very High Very High
Pain 41 75.00 Quite High
Hypertrophy 12 69.60 Quite High
Osteoarthritis 88 68.88 Quite High
Disease 10 66.48 Quite High
Weight Gain 4 12.12 Low Low
Fatigue 2 8.16 Low Low
Osteophyte 7 5.00 Very Low Very Low Very Low
Frailty 5 5.00 Very Low Very Low Very Low
Muscle Weakness 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A ventralizing effect of RA was also observed by upregulation of OLIG2 expression, probably at the expense of IRX3, in agreement with previous findings suggesting that OLIG2 suppresses IRX3 [59] and interacts with progenitor homeodomain proteins, thus activating motor neuron differentiation pathway and HB9 gene.
Positive_regulation (activating) of HB9 in motor neuron associated with rheumatoid arthritis
1) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346555 Disease Relevance 0.52 Pain Relevance 0.13
Osteochondral vascularity was elevated in MNX compared with SHAM-operated animals (P < 0.001) and reduced, dose-dependently, by MMP inhibitor treatment (r = ?
Positive_regulation (elevated) of MNX associated with metalloproteinase
2) Confidence 0.04 Published 2010 Journal Osteoarthritis and Cartilage Section Abstract Doc Link PMC2853084 Disease Relevance 0.59 Pain Relevance 0.66
Of interest we found that although no changes to the MHC protein composition were noted in response to clenbuterol prior to surgery, subtle effects of clenbuterol on MHC protein expression were observed in the period post surgery where clenbuterol suppressed the trend towards an MNX surgery-induced increase in MHC I.
Positive_regulation (increase) of MNX
3) Confidence 0.01 Published 2010 Journal Osteoarthritis and Cartilage Section Body Doc Link PMC2849930 Disease Relevance 0.30 Pain Relevance 0.18

General Comments

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