INT230633

Context Info Confidence 0.30 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 1.40 Pain Relevance 0.97

nucleus (MNX1)

Anatomy Link Frequency motor neuron 1 MNX1 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 41 96.68 Spinal cord 6 83.80 Pain 44 75.00 Osteoarthritis 89 68.88 agonist 11 62.84 Central nervous system 7 59.00 midbrain 5 51.64 Dopamine 9 44.88 Glutamate receptor 1 8.88 gABA 8 5.00

Disease Link Frequency Relevance Heat Rheumatoid Arthritis 21 95.50 Pain 41 75.00 Hypertrophy 12 69.60 Osteoarthritis 88 68.88 Disease 10 66.48 Weight Gain 4 12.12 Fatigue 2 8.16 Osteophyte 7 5.00 Frailty 5 5.00 Muscle Weakness 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A ventralizing effect of RA was also observed by upregulation of OLIG2 expression, probably at the expense of IRX3, in agreement with previous findings suggesting that OLIG2 suppresses IRX3 [59] and interacts with progenitor homeodomain proteins, thus activating motor neuron differentiation pathway and HB9 gene.

Positive_regulation (activating) of HB9 in motor neuron associated with rheumatoid arthritis

1) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346555 Disease Relevance 0.52 Pain Relevance 0.13

Osteochondral vascularity was elevated in MNX compared with SHAM-operated animals (P < 0.001) and reduced, dose-dependently, by MMP inhibitor treatment (r = ?

Positive_regulation (elevated) of MNX associated with metalloproteinase

2) Confidence 0.04 Published 2010 Journal Osteoarthritis and Cartilage Section Abstract Doc Link PMC2853084 Disease Relevance 0.59 Pain Relevance 0.66

Of interest we found that although no changes to the MHC protein composition were noted in response to clenbuterol prior to surgery, subtle effects of clenbuterol on MHC protein expression were observed in the period post surgery where clenbuterol suppressed the trend towards an MNX surgery-induced increase in MHC I.

Positive_regulation (increase) of MNX

3) Confidence 0.01 Published 2010 Journal Osteoarthritis and Cartilage Section Body Doc Link PMC2849930 Disease Relevance 0.30 Pain Relevance 0.18

General Comments

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