INT230653

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Context Info
Confidence 0.55
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.60
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Rasa1) plasma membrane (Rasa1) embryo development (Rasa1)
cytoplasm (Rasa1)
Anatomy Link Frequency
brachial plexus 2
Rasa1 (Mus musculus)
Pain Link Frequency Relevance Heat
Thalamus 2 88.16 High High
Neurotransmitter 4 68.16 Quite High
Spinal cord 50 63.76 Quite High
medulla 60 63.12 Quite High
cytokine 10 55.84 Quite High
metalloproteinase 2 45.36 Quite Low
Inflammatory mediators 2 41.00 Quite Low
Nerve growth factor 2 38.64 Quite Low
Inflammation 2 29.76 Quite Low
cerebral cortex 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 7 90.40 High High
Hamartoma 8 69.96 Quite High
Death 4 68.56 Quite High
Apoptosis 3 64.40 Quite High
Congenital Anomalies 4 50.20 Quite High
Tuberous Sclerosis 11 50.00 Quite Low
Adhesions 3 46.48 Quite Low
INFLAMMATION 6 40.60 Quite Low
Alzheimer's Dementia 2 28.76 Quite Low
Disease 26 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a complementary approach, CCNH and RASA1 were ectopically expressed in HIB1B cells, and mitochondrial density and oxidative phosphorylation were measured by FACS 72 hours later (Figure 4C).
Phosphorylation (phosphorylation) of RASA1
1) Confidence 0.55 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2346558 Disease Relevance 0.29 Pain Relevance 0
For example, when RGS2 was phosphorylated by PKC, GAP activity was reduced, then Gq/11 signals were enhanced [41]; RGS16 phosphorylation could also reduce its GAP activity toward GRi/o and result in increased adrenergic receptor signals [42], then the paralleled increase in RGS4 and PKA induced by brachial plexus avulsion will be expected to unmask their full functional potential, the orchestrated and dynamical RGS4 subcellular distribution and modulation will be the intriguing intracellular signal in response to brachial plexus avulsion.
Phosphorylation (phosphorylation) of GAP in brachial plexus
2) Confidence 0.10 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC3017042 Disease Relevance 0 Pain Relevance 0.22
For example, when RGS2 was phosphorylated by PKC, GAP activity was reduced, then Gq/11 signals were enhanced [41]; RGS16 phosphorylation could also reduce its GAP activity toward GRi/o and result in increased adrenergic receptor signals [42], then the paralleled increase in RGS4 and PKA induced by brachial plexus avulsion will be expected to unmask their full functional potential, the orchestrated and dynamical RGS4 subcellular distribution and modulation will be the intriguing intracellular signal in response to brachial plexus avulsion.
Phosphorylation (phosphorylated) of GAP in brachial plexus
3) Confidence 0.06 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC3017042 Disease Relevance 0 Pain Relevance 0.20
Phosphorylation of several sites on TSC1–2 stimulates the GAP function of TSC2, whereas phosphorylation of other sites inhibits it [37, 73, 91, 92].
Phosphorylation (Phosphorylation) of GAP
4) Confidence 0.02 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.31 Pain Relevance 0

General Comments

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