INT230668

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Context Info
Confidence 0.68
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.25
Pain Relevance 1.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Rasa1) plasma membrane (Rasa1) embryo development (Rasa1)
cytoplasm (Rasa1)
Anatomy Link Frequency
growth cone 2
CAR 1
Rasa1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 45 97.68 Very High Very High Very High
analgesia 22 97.32 Very High Very High Very High
agonist 59 94.48 High High
tolerance 51 90.64 High High
mu opioid receptor 26 83.68 Quite High
Hippocampus 27 82.40 Quite High
Thalamus 18 81.36 Quite High
fibrosis 3 78.80 Quite High
Clonidine 2 72.68 Quite High
Analgesic 64 71.32 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 242 98.08 Very High Very High Very High
Arrhythmia Under Development 57 97.38 Very High Very High Very High
Stroke 128 83.80 Quite High
Disease 38 81.36 Quite High
Fibrosis 3 78.80 Quite High
Pressure And Volume Under Development 6 78.08 Quite High
Frailty 5 70.68 Quite High
Heart Rate Under Development 15 68.60 Quite High
Congenital Anomalies 8 61.60 Quite High
Transient Ischemic Attack 2 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a complementary approach, CCNH and RASA1 were ectopically expressed in HIB1B cells, and mitochondrial density and oxidative phosphorylation were measured by FACS 72 hours later (Figure 4C).
Gene_expression (expressed) of RASA1
1) Confidence 0.68 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2346558 Disease Relevance 0.29 Pain Relevance 0
In contrast, down-regulation of RASA1 expression showed no effect.
Gene_expression (expression) of RASA1
2) Confidence 0.68 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2346558 Disease Relevance 0.26 Pain Relevance 0
Overexpression of CCNH, but not RASA1, resulted in significantly increased levels of mitochondrial density and oxidative phosphorylation, similar to those observed with overexpression of PGC-1?
Gene_expression (Overexpression) of RASA1
3) Confidence 0.68 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2346558 Disease Relevance 0.24 Pain Relevance 0
Because the dye-coupling experiments indicated a problem in cell–cell communication, we followed the structure and protein composition of the intercalated discs and the expression and localization of gap junction proteins.
Gene_expression (expression) of gap
4) Confidence 0.10 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556793 Disease Relevance 0.37 Pain Relevance 0
z-GTP subunits through reduction in the expression of its GAP, the RGSZ2 protein, leads to profound desensitization of morphine analgesia [47,54].
Gene_expression (expression) of GAP associated with analgesia and morphine
5) Confidence 0.09 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657119 Disease Relevance 0 Pain Relevance 1.35
The intercalated disc contains four different types of intercellular junctions, three of which have been linked to cardiac arrhythmia in human and animal models: gap junctions (with connexins forming channels for ion transfer), adherens junctions (with N-cadherin stabilizing gap junctions), and desmosomes (structural organization of the intercalated disc).
Gene_expression (stabilizing) of gap associated with arrhythmia under development
6) Confidence 0.09 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556793 Disease Relevance 0.75 Pain Relevance 0
With the severe AV block in the absence of atrial or ventricular arrhythmia mimicked in the Cx45 KO, we hypothesized that CAR (as described for N-cadherin; reference 6) affects electrical conduction indirectly through gap junctions.
Gene_expression (junctions) of gap in CAR associated with targeted disruption and arrhythmia under development
7) Confidence 0.08 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556793 Disease Relevance 0.95 Pain Relevance 0.04
To investigate the remodeling of functional pathways associated with long-term remodeling of the brain, we studied the expression of a protein (GAP-53), expressed in the axonal growth cone of growing axons [9, 47, 48].
Gene_expression (expression) of GAP-53 in growth cone
8) Confidence 0.02 Published 2007 Journal The Open Neuroimaging Journal Section Body Doc Link PMC2577937 Disease Relevance 0.20 Pain Relevance 0.17
To investigate the remodeling of functional pathways associated with long-term remodeling of the brain, we studied the expression of a protein (GAP-53), expressed in the axonal growth cone of growing axons [9, 47, 48].
Gene_expression (expressed) of GAP-53 in growth cone
9) Confidence 0.02 Published 2007 Journal The Open Neuroimaging Journal Section Body Doc Link PMC2577937 Disease Relevance 0.20 Pain Relevance 0.17

General Comments

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