INT230676

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Context Info
Confidence 0.34
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 5.61
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (4930579C15Rik) nucleus (4930579C15Rik) cytoplasm (4930579C15Rik)
Anatomy Link Frequency
band 5
Atlas 2
4930579C15Rik (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 4 90.64 High High
long-term potentiation 2 81.56 Quite High
ischemia 4 76.00 Quite High
Central nervous system 72 74.80 Quite High
Spinal cord 16 70.32 Quite High
Catecholamine 8 63.04 Quite High
adenocard 2 63.04 Quite High
gABA 4 24.84 Low Low
antagonist 4 21.96 Low Low
dopamine receptor 6 21.52 Low Low
Disease Link Frequency Relevance Heat
Injury 192 97.84 Very High Very High Very High
Sprains And Strains 366 97.48 Very High Very High Very High
Cancer 8 95.40 Very High Very High Very High
Neurodegenerative Disease 10 95.20 Very High Very High Very High
Heart Disease 8 94.92 High High
Diabetes Mellitus 12 94.32 High High
Disease 56 93.20 High High
Death 24 92.96 High High
Wound Healing 100 91.80 High High
Obesity 60 89.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression QTL (eQTL) analysis combines transcriptome profiling with linkage analysis to reveal chromosomal loci modulating expression variability (Darvasi, 2003; Broman, 2005; Chesler et al. 2005).
Gene_expression (expression) of eQTL
1) Confidence 0.34 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.95 Pain Relevance 0.15
Expression QTL (eQTL) analysis combines transcriptome profiling with linkage analysis to reveal chromosomal loci modulating expression variability (Darvasi, 2003; Broman, 2005; Chesler et al. 2005).
Gene_expression (Expression) of eQTL
2) Confidence 0.34 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.82 Pain Relevance 0.13
The chromosome 12 locus modulates the expression of genes located outside the 10-to 30-Mb locus (trans-eQTL) and of genes within the locus (cis-eQTL).
Gene_expression (expression) of eQTL
3) Confidence 0.31 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.90 Pain Relevance 0.03
The chromosome 12 locus modulates the expression of genes located outside the 10-to 30-Mb locus (trans-eQTL) and of genes within the locus (cis-eQTL).
Gene_expression (expression) of eQTL
4) Confidence 0.31 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.90 Pain Relevance 0.03
For each trans-eQTL band, we performed a functional enrichment analysis over all FGS based on the hypergeometric distribution and a variable significance threshold (see Methods).
Gene_expression (band) of eQTL in band
5) Confidence 0.24 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2346558 Disease Relevance 0 Pain Relevance 0
For all significant trans-eQTL bands with FGS enrichment, we computed the median pairwise correlation coefficient in the Gene Atlas for eQTL/FGS genes (Figure 3A).
Gene_expression (bands) of eQTL in Atlas
6) Confidence 0.24 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2346558 Disease Relevance 0.18 Pain Relevance 0
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Gene_expression (bands) of eQTL in bands
7) Confidence 0.24 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2346558 Disease Relevance 0 Pain Relevance 0
These expression QTL (eQTL) studies have provided important clues as to the genetic basis of gene expression regulation.
Gene_expression (expression) of eQTL
8) Confidence 0.24 Published 2008 Journal PLoS Genetics Section Abstract Doc Link PMC2346558 Disease Relevance 0.47 Pain Relevance 0
Whereas eQTL analysis was based on expression data from a single tissue across many strains of mice, the Gene Atlas data set measured expression of a single strain across many diverse anatomic tissues.
Gene_expression (analysis) of eQTL in Atlas associated with sprains and strains
9) Confidence 0.24 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2346558 Disease Relevance 0.25 Pain Relevance 0
This hypothesis is corroborated by an observed association between expression of CCNH and haplotype structure at the trans-eQTL band locus (p?
Gene_expression (expression) of eQTL in band
10) Confidence 0.21 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2346558 Disease Relevance 0.15 Pain Relevance 0
The presence of cis-eQTLs for many gene expression phenotypes produced a cis-eQTL band, visible as the diagonal line in Figure 1.
Gene_expression (produced) of eQTL in band
11) Confidence 0.21 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2346558 Disease Relevance 0.19 Pain Relevance 0
This novel regulatory role for cyclin H in the regulation of oxidative phosphorylation was one of the 1593 trans-eQTL band enrichments detected in the adipose eQTL analysis.
Gene_expression (detected) of eQTL in band
12) Confidence 0.21 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2346558 Disease Relevance 0.05 Pain Relevance 0
In this study we have identified the sequence variant underlying a strong cis-acting expression quantitative trait locus (eQTL) for the Comt gene.
Gene_expression (expression) of eQTL
13) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.31 Pain Relevance 0.12
For this reason we closely examined this variant to understand the mechanisms that generate the strong cis eQTL.


Gene_expression (generate) of eQTL
14) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.43 Pain Relevance 0.03

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