INT230679

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.42
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Gsk3b) carbohydrate metabolic process (Gsk3b) protein complex (Gsk3b)
response to stress (Gsk3b) cytoplasm (Gsk3b) cytosol (Gsk3b)
Gsk3b (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 4 88.40 High High
cINOD 4 82.64 Quite High
Hippocampus 4 76.20 Quite High
cerebral cortex 1 75.56 Quite High
agonist 11 62.40 Quite High
imagery 5 60.72 Quite High
Kinase C 13 50.64 Quite High
depression 7 47.36 Quite Low
fluoxetine 3 42.40 Quite Low
sSRI 2 41.92 Quite Low
Disease Link Frequency Relevance Heat
Disease 80 99.22 Very High Very High Very High
Drug Induced Neurotoxicity 12 92.80 High High
INFLAMMATION 5 88.40 High High
Targeted Disruption 12 88.16 High High
Infection 2 74.32 Quite High
Toxicity 7 72.24 Quite High
Stress 3 61.76 Quite High
Apoptosis 13 51.60 Quite High
Depression 7 47.36 Quite Low
Alzheimer's Dementia 5 19.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gsk3b is a proline-directed serine-threonine kinase that was initially identified for its role phosphorylating and inactivating glycogen synthase [22].
Positive_regulation (directed) of Gsk3b Binding (proline) of
1) Confidence 0.42 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2346558 Disease Relevance 0 Pain Relevance 0
Moreover, it is possible that, in Alzheimer's disease, aberrant HDAC6 levels are induced by increased activity of GSK3?
Positive_regulation (increased) of GSK3 Binding (activity) of associated with disease
2) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0.64 Pain Relevance 0.13
The protection observed is the result of the Wnt signaling activation, since the increase in the activity of GSK-3?
Positive_regulation (increase) of GSK-3 Binding (activity) of
3) Confidence 0.08 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.77 Pain Relevance 0.44

General Comments

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