INT230716

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Context Info
Confidence 0.10
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.26
Pain Relevance 1.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (GOPC) plasma membrane (GOPC) cytoplasm (GOPC)
GOPC (Homo sapiens)
Pain Link Frequency Relevance Heat
Neurotransmitter 6 98.92 Very High Very High Very High
Nav1.7 24 98.08 Very High Very High Very High
nav1.8 10 96.80 Very High Very High Very High
adenocard 74 94.56 High High
Neuropathic pain 13 93.92 High High
sodium channel 21 70.44 Quite High
Peripheral nervous system 5 69.80 Quite High
Mexiletine 1 66.84 Quite High
Analgesic 6 46.72 Quite Low
agonist 77 46.24 Quite Low
Disease Link Frequency Relevance Heat
Epilepsy 1 94.44 High High
Neuropathic Pain 13 93.92 High High
Nociception 2 44.48 Quite Low
Hypersensitivity 1 40.96 Quite Low
Nervous System Injury 1 39.52 Quite Low
Pain 17 17.52 Low Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 4 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fig1Binding of an allosteric ligand (1) modulates the binding of hormone or neurotransmitter (2)
Regulation (modulates) of Fig Binding (1Binding) of associated with neurotransmitter
1) Confidence 0.10 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721769 Disease Relevance 0 Pain Relevance 0.27
The binding of modulators is supposed to result in conformational changes of the receptor that affect binding of the orthosteric ligand with consequences for receptor activity (see Fig. 1).
Regulation (affect) of Fig Binding (binding) of
2) Confidence 0.06 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721769 Disease Relevance 0 Pain Relevance 0.28
For example, compound 2 of Fig. 2 was highly state dependent and ?
Regulation (dependent) of Fig Binding (compound) of
3) Confidence 0.03 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2346569 Disease Relevance 0.26 Pain Relevance 1.04

General Comments

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