INT230724

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Context Info
Confidence 0.24
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 4.12
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (EDNRA) signal transducer activity (EDNRA) cell-cell signaling (EDN1)
cytoplasm (EDN1) cell proliferation (EDNRA) extracellular space (EDN1)
EDN1 (Homo sapiens)
EDNRA (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 5 97.92 Very High Very High Very High
fibrosis 3 97.64 Very High Very High Very High
antagonist 15 84.16 Quite High
ischemia 3 76.04 Quite High
metalloproteinase 4 44.48 Quite Low
peripheral neuropathy 2 10.00 Low Low
nud 2 7.56 Low Low
imagery 12 5.00 Very Low Very Low Very Low
cva 11 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 150 99.56 Very High Very High Very High
Coronary Heart Disease 5 99.16 Very High Very High Very High
INFLAMMATION 5 97.92 Very High Very High Very High
Fibrosis 3 97.64 Very High Very High Very High
Increased Venous Pressure Under Development 26 97.24 Very High Very High Very High
Diabetes Mellitus 53 97.16 Very High Very High Very High
Pulmonary Hypertension 162 96.60 Very High Very High Very High
Metastasis 6 96.56 Very High Very High Very High
Ovarian Cancer 200 96.00 Very High Very High Very High
Vascular Disease 1 95.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results suggest that ET-1, through activation of the ETA receptor, is of importance for the regulation of the microcirculation in diabetic patients with micro-angiopathy.
ET-1 Positive_regulation (activation) of ETA associated with vascular disease and diabetes mellitus
1) Confidence 0.24 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605330 Disease Relevance 0.96 Pain Relevance 0.04
Activation of the ETA receptor (ETAR) by ET-1 increases tumor cell proliferation, survival, angiogenesis, migration, invasion, and metastasis in ovarian cancer [79].
ET-1 Positive_regulation (Activation) of ETAR associated with cancer, ovarian cancer and metastasis
2) Confidence 0.11 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2804796 Disease Relevance 0.98 Pain Relevance 0.03
Activation of the ETA receptor (ETAR) by ET-1 increases tumor cell proliferation, survival, angiogenesis, migration, invasion, and metastasis in ovarian cancer [79].
ET-1 Positive_regulation (Activation) of ETA receptor associated with cancer, ovarian cancer and metastasis
3) Confidence 0.01 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2804796 Disease Relevance 0.98 Pain Relevance 0.03
Furthermore, stimulation of both ETA and ETB receptors by endothelin is important in the myocardial hypertrophy and myocardial fibrosis which is seen in PAH (Levin 1995).
endothelin Positive_regulation (stimulation) of ETA associated with fibrosis, pulmonary hypertension and coronary heart disease
4) Confidence 0.00 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350123 Disease Relevance 1.20 Pain Relevance 0.30

General Comments

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