INT230740

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Context Info
Confidence 0.15
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 3.50
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Agtr1a) signal transduction (Agtr1a) Golgi apparatus (Agtr1a)
plasma membrane (Agtr1a) cytoplasm (Agtr1a) signal transducer activity (Agtr1a)
Agtr1a (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 4 95.04 Very High Very High Very High
Inflammation 41 92.24 High High
Calcium channel 1 38.60 Quite Low
antagonist 14 37.88 Quite Low
anesthesia 2 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
Inflammatory marker 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 42 99.84 Very High Very High Very High
Hypertension 34 96.04 Very High Very High Very High
Diabetes Mellitus 7 95.52 Very High Very High Very High
INFLAMMATION 38 94.64 High High
Apoptosis 30 94.64 High High
Cancer 168 94.24 High High
Adhesions 6 82.92 Quite High
Renal Disease 1 81.64 Quite High
Cardiovascular Disease 11 74.48 Quite High
Pressure And Volume Under Development 3 70.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Responses of the AT1 receptor are typically associated with stimulation of growth factor receptors leading to cell growth, proliferation, cell migration, apoptosis, and gene expression [10,11].
Regulation (Responses) of AT1 associated with apoptosis
1) Confidence 0.15 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2846883 Disease Relevance 0.98 Pain Relevance 0
In support of this speculation, Fujimoto et al. [39] have reported AT1 receptor over-expression in human pancreatic cancer tissues and AT1 receptor-mediated growth regulation in pancreatic cancer cells.
Regulation (regulation) of AT1 associated with pancreatic cancer
2) Confidence 0.15 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2846883 Disease Relevance 1.19 Pain Relevance 0
Furthermore, CRP-induced up-regulation of the angiotensin type 1 receptor was attenuated by losartan (Wang et al 2003).
Regulation (regulation) of angiotensin type 1 receptor
3) Confidence 0.10 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350124 Disease Relevance 1.33 Pain Relevance 0.19

General Comments

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