INT230748

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Context Info
Confidence 0.05
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.04
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Agtr2, Ros1) plasma membrane (Agtr2, Ros1) cell differentiation (Ros1)
cell proliferation (Ros1) kinase activity (Ros1) transcription factor binding (Agtr2)
Agtr2 (Mus musculus)
Ros1 (Mus musculus)
Pain Link Frequency Relevance Heat
Bioavailability 2 89.88 High High
Inflammation 46 85.68 High High
Neurotransmitter 2 59.48 Quite High
cytokine 1 58.16 Quite High
tetrodotoxin 1 51.20 Quite High
Inflammatory mediators 4 16.96 Low Low
Angina 2 5.00 Very Low Very Low Very Low
Inflammatory marker 2 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Calcium channel 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophy 3 96.24 Very High Very High Very High
Coronary Heart Disease 1 95.52 Very High Very High Very High
Diabetes Mellitus 134 93.28 High High
Vasculitis 10 86.40 High High
Increased Venous Pressure Under Development 5 78.00 Quite High
Stress 23 70.72 Quite High
Adhesions 6 64.16 Quite High
INFLAMMATION 43 60.24 Quite High
Hyperplasia 1 54.56 Quite High
Neurodegenerative Disease 8 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increase is cancelled by the NADH/NADPH oxidase inhibitor that reduces intracellular ROS, indicating that angiotensin II stimulates ROS production via AT1R and NADH/NADPH oxidase, to activate ERK [36].
angiotensin II Positive_regulation (stimulates) of Gene_expression (production) of ROS
1) Confidence 0.05 Published 2010 Journal Diabetologia Section Body Doc Link PMC2850533 Disease Relevance 0.48 Pain Relevance 0.08
Increased ROS production induced by angiotensin II is involved in the mechanisms leading to vascular remodeling, through VSMC proliferation and hypertrophy and collagen deposition (Touyz and Schiffrin 2001).
angiotensin II Positive_regulation (induced) of Gene_expression (production) of ROS associated with hypertrophy
2) Confidence 0.01 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350124 Disease Relevance 0.55 Pain Relevance 0.15

General Comments

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