INT230751

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Context Info
Confidence 0.03
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.30
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpine1) signal transduction (Agtr2) extracellular region (Serpine1)
plasma membrane (Agtr2) transcription factor binding (Agtr2) signal transducer activity (Agtr2)
Anatomy Link Frequency
plaque 2
Agtr2 (Mus musculus)
Serpine1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 1 94.84 High High
Inflammatory mediators 4 86.80 High High
Inflammation 41 85.20 High High
Bioavailability 2 32.68 Quite Low
Angina 2 5.00 Very Low Very Low Very Low
Inflammatory marker 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Calcium channel 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rupture 4 98.64 Very High Very High Very High
Atherosclerosis 3 95.56 Very High Very High Very High
Vasculitis 10 88.48 High High
INFLAMMATION 38 86.40 High High
Stress 4 76.36 Quite High
Infection 1 71.28 Quite High
Malignant Neoplastic Disease 1 69.04 Quite High
Hypertrophy 3 64.24 Quite High
Increased Venous Pressure Under Development 4 56.00 Quite High
Cardiovascular Disease 11 35.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, angiotensin II stimulates the production of plasminogen activator inhibitor-I (PAI-1) (Vaughan et al 1995), which may contribute not only to the prothrombotic state but also to plaque rupture in atherosclerotic lesions.


angiotensin II Positive_regulation (stimulates) of Gene_expression (production) of PAI-1 in plaque associated with atherosclerosis and rupture
1) Confidence 0.03 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350124 Disease Relevance 1.30 Pain Relevance 0.23

General Comments

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