INT230758

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 6.04
Pain Relevance 2.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PTPRC)
Anatomy Link Frequency
hematopoietic cells 4
monocytes 2
leukocytes 2
bone marrow 2
lung 2
PTPRC (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 238 99.96 Very High Very High Very High
Arthritis 85 98.68 Very High Very High Very High
rheumatoid arthritis 23 95.32 Very High Very High Very High
imagery 63 94.88 High High
Spinal cord 38 93.08 High High
cytokine 106 89.52 High High
diabetic neuropathy 7 88.00 High High
chemokine 37 87.68 High High
positron emission tomography 39 87.44 High High
Glutamate 6 87.16 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 274 99.96 Very High Very High Very High
Adhesions 36 99.96 Very High Very High Very High
Hyperglycemia 9 99.84 Very High Very High Very High
Adenocarcinoma 5 99.64 Very High Very High Very High
Rheumatoid Arthritis 34 99.48 Very High Very High Very High
Cancer 92 98.94 Very High Very High Very High
Diabetic Macular Edema 9 98.84 Very High Very High Very High
Seronegative Spondarthritis 80 98.68 Very High Very High Very High
Skin Cancer 4 97.84 Very High Very High Very High
Infection 15 94.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this gate, CECs were identified as positive for the specific marker CD146 (melanoma cell adhesion molecule (MCAM), a cell-adhesion molecule used as a marker for endothelial cell lineage) and negative for the hematopoietic marker CD45 (PTPRC, present on all differentiated hematopoietic cells; Figure 1).
Positive_regulation (negative) of Neg (negative) Gene_expression (negative) of CD45 in hematopoietic cells associated with skin cancer and adhesions
1) Confidence 0.49 Published 2010 Journal Crit Care Section Body Doc Link PMC2911749 Disease Relevance 0.29 Pain Relevance 0
Consistent with other studies using a similar approach [49], preliminary experiments using the same conditioning regimen and transplanting CD45.1+ bone marrow into irradiated CD45.1?
Positive_regulation (irradiated) of Gene_expression (transplanting) of CD45 in bone marrow
2) Confidence 0.49 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504049 Disease Relevance 0.36 Pain Relevance 0.03
In this gate, CECs were identified as positive for the specific marker CD146 (melanoma cell adhesion molecule (MCAM), a cell-adhesion molecule used as a marker for endothelial cell lineage) and negative for the hematopoietic marker CD45 (PTPRC, present on all differentiated hematopoietic cells; Figure 1).
Positive_regulation (negative) of Neg (negative) Gene_expression (negative) of PTPRC in hematopoietic cells associated with skin cancer and adhesions
3) Confidence 0.49 Published 2010 Journal Crit Care Section Body Doc Link PMC2911749 Disease Relevance 0.29 Pain Relevance 0
The identity of gated cells was further confirmed to be microglial, as opposed to intravascular neutrophils or monocytes, by their lower levels of CD45 expression (Sedgwick et al., 1991) in control and injured rats (data not shown).
Positive_regulation (levels) of Gene_expression (expression) of CD45 in monocytes
4) Confidence 0.45 Published 2007 Journal J Neurosci Methods Section Body Doc Link PMC2726922 Disease Relevance 0.06 Pain Relevance 0.05
was correlated to IL-6 levels in SF as well as to CD45 expression in ST and MIP-1 ?
Positive_regulation (correlated) of Gene_expression (expression) of CD45
5) Confidence 0.23 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945042 Disease Relevance 1.34 Pain Relevance 0.78
blockers induced a significant down-regulation in CD45 (1157.0 ± 712.9 and 545.8 ± 253.2, P = 0.007) and CD3 (402.8 ± 203.0 and 224.8 ± 107.7, P = 0.039) ST expression.


Positive_regulation (induced) of Gene_expression (expression) of CD45
6) Confidence 0.19 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945042 Disease Relevance 0.28 Pain Relevance 0.17
These cells displayed spindle-shape morphology and were identified by their expression for CD73, CD105, CD90 but negative for all hematopoietic markers (CD45, CD34, HLA-Dr).
Positive_regulation (negative) of Gene_expression (expression) of CD45
7) Confidence 0.13 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2358905 Disease Relevance 0.18 Pain Relevance 0.04
CD45-CyC, RP-1-PE and ED1-PE were obtained by BD Biosciences, Heidelberg, Germany and Serotec, London, Great Britain, respectively

Animals and complete Freund's adjuvant-induced inflammation

Positive_regulation (induced) of Gene_expression (obtained) of CD45 associated with inflammation
8) Confidence 0.08 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 0.28 Pain Relevance 0.49
Heat maps depicting the edge weights ra, b linking gene sets are presented in Figure 5 for both empiric and LCA classes.
Positive_regulation (presented) of Gene_expression (classes) of LCA in edge associated with rheumatoid arthritis
9) Confidence 0.05 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2569951 Disease Relevance 0.37 Pain Relevance 0
VEGF is a glycoprotein whose production is increased in hyperglycemia, primarily through the PKC pathway.
Positive_regulation (increased) of Gene_expression (production) of glycoprotein associated with hyperglycemia
10) Confidence 0.01 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350125 Disease Relevance 0.94 Pain Relevance 0.13
In that regard, tumor-associated glycoprotein-72 (TAG-72) is a mucin-like glycoprotein complex that is overexpressed by many adenocarcinomas, including colorectal, pancreatic, gastric, esophageal, ovarian, endometrial, breast, prostate, and lung [22,24-27].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of glycoprotein in lung associated with adenocarcinoma and cancer
11) Confidence 0.01 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2924340 Disease Relevance 0.88 Pain Relevance 0.33
from macrophages induce the expression of glycoprotein adhesion molecules on the surface of vascular endothelial cells which bind leukocytes so they can leave the circulation and enter the site of infection.


Positive_regulation (induce) of Gene_expression (expression) of glycoprotein in leukocytes associated with infection and adhesions
12) Confidence 0.01 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671742 Disease Relevance 0.76 Pain Relevance 0.43

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