INT230761

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Context Info
Confidence 0.02
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.16
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (VEGFA, Kdr) extracellular space (VEGFA) growth (VEGFA)
extracellular region (VEGFA) proteinaceous extracellular matrix (VEGFA) plasma membrane (Kdr)
Anatomy Link Frequency
endothelial cells 1
retina 1
VEGFA (Homo sapiens)
Kdr (Mus musculus)
Pain Link Frequency Relevance Heat
diabetic neuropathy 7 84.16 Quite High
imagery 6 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
peripheral neuropathy 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperglycemia 9 98.52 Very High Very High Very High
Diabetic Macular Edema 9 95.00 High High
Metastasis 62 86.40 High High
Peripheral Neuropathy 9 84.16 Quite High
Cancer 116 83.68 Quite High
Diabetes Mellitus 56 81.76 Quite High
Lymphatic Metastasis 2 75.76 Quite High
Breast Cancer 6 68.56 Quite High
Albuminuria 4 65.32 Quite High
Age-related Macular Degeneration 7 52.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The growth of blood vessels (angiogenesis) is primarily initiated by activation of VEGFR-1 and VEGFR-2 by VEGF-A, whereas lymphangiogenesis is predominantly driven by VEGF-C, which activates VEGFR-2 and VEGFR-3 expressed in lymphatic endothelial cells.
VEGF Positive_regulation (activates) of VEGFR-2 in endothelial cells
1) Confidence 0.02 Published 2010 Journal BMC Med Section Body Doc Link PMC2989928 Disease Relevance 1.19 Pain Relevance 0
VEGF mediates its effects on the retina through the receptor tyrosine kinases VEGFR-1 and VEGFR-2 (Shen et al 1993; Ferrara 2004).
VEGF Positive_regulation (mediates) of VEGFR in retina
2) Confidence 0.02 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350125 Disease Relevance 0.96 Pain Relevance 0.12

General Comments

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