INT230786

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.15
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.53
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (AGT, ACE) extracellular region (AGT, ACE) endosome (ACE)
small molecule metabolic process (AGT) aging (AGT) extracellular matrix organization (AGT)
Anatomy Link Frequency
plasma 1
AGT (Homo sapiens)
ACE (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 1 94.24 High High
ischemia 14 94.08 High High
Inflammation 6 91.04 High High
Catecholamine 5 78.40 Quite High
medulla 2 75.84 Quite High
bradykinin 6 42.88 Quite Low
substance P 4 41.68 Quite Low
Bioavailability 13 5.00 Very Low Very Low Very Low
withdrawal 9 5.00 Very Low Very Low Very Low
Potency 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sepsis 44 99.12 Very High Very High Very High
Internal Fibrosis 1 94.24 High High
Cv Unclassified Under Development 11 94.08 High High
Vasculitis 1 91.04 High High
Increased Venous Pressure Under Development 21 88.80 High High
Pressure And Volume Under Development 35 87.12 High High
Heart Rate Under Development 8 85.44 High High
Chronic Renal Failure 8 82.40 Quite High
Injury 2 81.08 Quite High
Diabetes Mellitus 117 80.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ACE: Angiotensin converting enzyme; Ang II: plasma concentration of angiotensin II; EDTA: ethylenediaminetetraacetate; NIRS: near infrared spectroscopy; PRA: plasma renin activity; RAS: Renin-Angiotensin System; RIA: radioimmune assay; SOFA: Sequential Organ Failure Assessment score; SpO2: percent oxygen saturation of arterial hemoglobin: as measured with pulse oximetry; StO2: percent oxygen saturation of microvascular (tissue) hemoglobin: as measured with NIRS.


angiotensin II Binding (concentration) of Angiotensin converting enzyme in plasma
1) Confidence 0.15 Published 2010 Journal Crit Care Section Body Doc Link PMC2875539 Disease Relevance 0.79 Pain Relevance 0.09
Although ACE inhibitors are able to reduce angiotensin II formation, non-ACE dependent pathways have also been identified.137 On the other hand, ARBs antagonize the binding of angiotensin II to the AT1 receptor, which mediates most of the undesirable effects associated with angiotensin II.
angiotensin Binding (binding) of non-ACE
2) Confidence 0.04 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2686259 Disease Relevance 0.66 Pain Relevance 0.09
Renin cleaves angiotensinogen to form the inactive decapeptide angiotensin I (Ang I) which is then converted by angiotensin-converting enzyme (ACE) to the active octapeptide Ang II, the effector enzyme of the cascade.
angiotensin I Binding (converted) of ACE
3) Confidence 0.03 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350136 Disease Relevance 0.54 Pain Relevance 0.08
Renin cleaves angiotensinogen to form the inactive decapeptide angiotensin I (Ang I) which is then converted by angiotensin-converting enzyme (ACE) to the active octapeptide Ang II, the effector enzyme of the cascade.
angiotensin I Binding (converted) of angiotensin-converting enzyme
4) Confidence 0.03 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350136 Disease Relevance 0.54 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox