INT230796

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.81
First Reported 2007
Last Reported 2011
Negated 0
Speculated 3
Reported most in Body
Documents 70
Total Number 77
Disease Relevance 31.73
Pain Relevance 4.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Irs1) signal transduction (Irs1) plasma membrane (Irs1)
nucleus (Irs1) cytoplasm (Irs1) signal transducer activity (Irs1)
Anatomy Link Frequency
fat 9
myocytes 3
skeletal muscle 3
adipocytes 3
liver 2
Irs1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 564 99.84 Very High Very High Very High
bradykinin 3 98.28 Very High Very High Very High
Inflammatory stimuli 42 97.12 Very High Very High Very High
Inflammation 409 95.32 Very High Very High Very High
Kinase C 99 95.24 Very High Very High Very High
tolerance 463 87.72 High High
Bioavailability 5 80.04 Quite High
Inflammatory mediators 16 75.12 Quite High
Pain 7 53.20 Quite High
Hippocampus 20 48.56 Quite Low
Disease Link Frequency Relevance Heat
Hyperinsulinism 115 99.76 Very High Very High Very High
Obesity 1431 99.40 Very High Very High Very High
Insulin Resistance 1557 99.30 Very High Very High Very High
Hepatocellular Cancer 37 99.28 Very High Very High Very High
Diabetes Mellitus 761 98.68 Very High Very High Very High
Targeted Disruption 398 97.72 Very High Very High Very High
Hypertrophy 46 97.32 Very High Very High Very High
INFLAMMATION 466 96.80 Very High Very High Very High
Disease 321 95.44 Very High Very High Very High
Stress 153 90.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, our study supports the hypothesis that high-fat diet–induced insulin resistance in skeletal muscle is mediated at least in part through increased serine phosphorylation of IRS-1.
Phosphorylation (phosphorylation) of IRS-1 in skeletal muscle associated with insulin resistance
1) Confidence 0.81 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.67 Pain Relevance 0
Intramyocellular fatty acid metabolites, such as diacylglycerol, have been postulated to activate a serine kinase cascade leading to increased serine phosphorylation of IRS-1.
Phosphorylation (phosphorylation) of IRS-1
2) Confidence 0.81 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.90 Pain Relevance 0.08
The data in the present study support the hypothesis that in vivo IRS-1 serine phosphorylation intereferes with IRS-1 tyrosine phosphorylation by the first three mechanisms, since we found increased insulin-stimulated IRS-1 tyrosine phosphorylation in the Tg IRS-1 Ser?
Phosphorylation (phosphorylation) of IRS-1 associated with hyperinsulinism
3) Confidence 0.81 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.16 Pain Relevance 0.05
To evaluate previous reports regarding increased serine phosphorylation on IRS-1 in skeletal muscle, we tested Ser307 and Ser612 residues using high-fat–fed mice and ob/ob mice.
Phosphorylation (phosphorylation) of IRS-1 in skeletal muscle associated with obesity
4) Confidence 0.81 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.40 Pain Relevance 0
Our study demonstrates that serine phosphorylation on IRS-1 is a key molecular event in the pathogenesis of fat-induced insulin resistance in vivo.
Phosphorylation (phosphorylation) of IRS-1 in fat associated with insulin resistance
5) Confidence 0.81 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.57 Pain Relevance 0.03
The data in the present study support the hypothesis that in vivo IRS-1 serine phosphorylation intereferes with IRS-1 tyrosine phosphorylation by the first three mechanisms, since we found increased insulin-stimulated IRS-1 tyrosine phosphorylation in the Tg IRS-1 Ser?
Phosphorylation (phosphorylation) of IRS-1 Ser associated with hyperinsulinism
6) Confidence 0.81 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.15 Pain Relevance 0.07
Increased serine phosphorylation of IRS-1 has been suggested to be responsible for this phenomenon (6), and, consistent with this hypothesis, recent studies have demonstrated hyperserine phosphorylation of IRS-1 on Ser302, Ser307, Ser612, and Ser636 in several insulin-resistant rodent models (7–10), as well as in lean insulin-resistant offspring of type 2 diabetic parents (11).
Phosphorylation (phosphorylation) of IRS-1 associated with diabetes mellitus
7) Confidence 0.81 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.97 Pain Relevance 0.04
The data in the present study support the hypothesis that in vivo IRS-1 serine phosphorylation intereferes with IRS-1 tyrosine phosphorylation by the first three mechanisms, since we found increased insulin-stimulated IRS-1 tyrosine phosphorylation in the Tg IRS-1 Ser?
Phosphorylation (phosphorylation) of IRS-1 associated with hyperinsulinism
8) Confidence 0.81 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.16 Pain Relevance 0.05
Previous in vitro studies speculated four possible mechanisms by which serine phosphorylation of IRS-1 can inhibit the insulin-signaling pathway.
Phosphorylation (phosphorylation) of IRS-1
9) Confidence 0.81 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.44 Pain Relevance 0.03
The data in the present study support the hypothesis that in vivo IRS-1 serine phosphorylation intereferes with IRS-1 tyrosine phosphorylation by the first three mechanisms, since we found increased insulin-stimulated IRS-1 tyrosine phosphorylation in the Tg IRS-1 Ser?
Phosphorylation (phosphorylation) of IRS-1 associated with hyperinsulinism
10) Confidence 0.81 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.15 Pain Relevance 0.07
Finally, serine phosphorylation or IRS-1 on certain sites such as Ser307 has been shown to promote protein degradation through the ubiquitin-proteosome pathway and/or the suppressor of cytokine-signaling pathway (34–36).
Phosphorylation (phosphorylation) of IRS-1 associated with cytokine
11) Confidence 0.81 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.25 Pain Relevance 0.05
Furthermore, tyrosine phosphorylation of IRS-1 was increased by 88% in Tg IRS-1 Ser?
Phosphorylation (phosphorylation) of IRS-1
12) Confidence 0.81 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.13 Pain Relevance 0.03
Increased serine phosphorylation of IRS-1 has been suggested to be responsible for this phenomenon (6), and, consistent with this hypothesis, recent studies have demonstrated hyperserine phosphorylation of IRS-1 on Ser302, Ser307, Ser612, and Ser636 in several insulin-resistant rodent models (7–10), as well as in lean insulin-resistant offspring of type 2 diabetic parents (11).
Phosphorylation (phosphorylation) of IRS-1 associated with diabetes mellitus
13) Confidence 0.81 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.94 Pain Relevance 0.03
Second, serine phosphorylation has been shown to interfere with the tyrosine phosphorylation of IRS-1 (32).
Phosphorylation (phosphorylation) of IRS-1
14) Confidence 0.81 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.31 Pain Relevance 0.04
CONCLUSIONS—These data demonstrate that serine phosphorylation of IRS-1 plays an important role in mediating fat-induced insulin resistance in skeletal muscle in vivo.



Phosphorylation (phosphorylation) of IRS-1 in fat associated with insulin resistance
15) Confidence 0.81 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2551673 Disease Relevance 0.82 Pain Relevance 0.08
To investigate the role of serine phosphorylation on IRS-1 in mediating fat-induced insulin resistance, we generated skeletal muscle–specific transgenic mice with triple mutations in Ser302, Ser307, and Ser612 to Ala using the 1.2-kb enhancer/promoter region of the myosin light-chain-2 gene (Fig. 1B).
Spec (investigate) Phosphorylation (phosphorylation) of IRS-1 in skeletal muscle associated with targeted disruption and insulin resistance
16) Confidence 0.80 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.60 Pain Relevance 0
On the other hand, our data suggest that IRS-1 serine phosphorylation does not lead to increased IRS-1 degradation by activation of the ubiquitin-proteosome or suppressor of cytokine-signaling pathway, since IRS-1 protein expression was unchanged after 8 weeks of high-fat diet treatment (Fig. 1A).
Phosphorylation (phosphorylation) of IRS-1 in fat associated with cytokine
17) Confidence 0.80 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.21 Pain Relevance 0.08
However, it remains unknown whether increased IRS-1 serine phosphorylation plays a causative role in the pathogenesis of fat-induced insulin resistance in skeletal muscle or whether it is merely an associated phenomenon.
Spec (whether) Phosphorylation (phosphorylation) of IRS-1 in fat associated with insulin resistance
18) Confidence 0.80 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.67 Pain Relevance 0.12
We found no increase in IGF-1 receptor tyrosine phosphorylation or IRS1/2 associated p85 following resistance exercise and, from 30 minutes, p85 associated with IRS1/2 was reduced.
Phosphorylation (phosphorylation) of IRS1
19) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.07 Pain Relevance 0
Increased serine phosphorylation of IRS-1 has been suggested to be responsible for this phenomenon (6), and, consistent with this hypothesis, recent studies have demonstrated hyperserine phosphorylation of IRS-1 on Ser302, Ser307, Ser612, and Ser636 in several insulin-resistant rodent models (7–10), as well as in lean insulin-resistant offspring of type 2 diabetic parents (11).
Phosphorylation (phosphorylation) of IRS-1 associated with diabetes mellitus
20) Confidence 0.62 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.97 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox