INT230799

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Context Info
Confidence 0.69
First Reported 2007
Last Reported 2011
Negated 4
Speculated 1
Reported most in Body
Documents 28
Total Number 29
Disease Relevance 11.17
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Irs1) signal transduction (Irs1) plasma membrane (Irs1)
nucleus (Irs1) cytoplasm (Irs1) signal transducer activity (Irs1)
Anatomy Link Frequency
fat 8
skeletal muscle 4
liver 2
3T3-L1 2
adipocyte 2
Irs1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 245 100.00 Very High Very High Very High
bradykinin 3 98.28 Very High Very High Very High
Kinase C 36 95.64 Very High Very High Very High
Inflammation 153 91.92 High High
Inflammatory mediators 8 76.48 Quite High
tolerance 155 69.84 Quite High
Hippocampus 10 49.04 Quite Low
cerebral cortex 3 48.24 Quite Low
Pyramidal cell 2 46.40 Quite Low
Inflammatory stimuli 22 30.40 Quite Low
Disease Link Frequency Relevance Heat
Hyperinsulinism 38 100.00 Very High Very High Very High
Insulin Resistance 498 99.96 Very High Very High Very High
Diabetes Mellitus 247 99.36 Very High Very High Very High
Hypertrophy 45 98.56 Very High Very High Very High
Obesity 594 97.32 Very High Very High Very High
Disease 112 95.92 Very High Very High Very High
Targeted Disruption 157 94.12 High High
INFLAMMATION 186 91.92 High High
Necrosis 29 84.72 Quite High
Cancer 40 84.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased serine phosphorylation of IRS-1 has been suggested to be responsible for this phenomenon (6), and, consistent with this hypothesis, recent studies have demonstrated hyperserine phosphorylation of IRS-1 on Ser302, Ser307, Ser612, and Ser636 in several insulin-resistant rodent models (7–10), as well as in lean insulin-resistant offspring of type 2 diabetic parents (11).
Positive_regulation (Increased) of Phosphorylation (phosphorylation) of IRS-1 associated with diabetes mellitus
1) Confidence 0.69 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.94 Pain Relevance 0.03
The data in the present study support the hypothesis that in vivo IRS-1 serine phosphorylation intereferes with IRS-1 tyrosine phosphorylation by the first three mechanisms, since we found increased insulin-stimulated IRS-1 tyrosine phosphorylation in the Tg IRS-1 Ser?
Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of IRS-1 associated with hyperinsulinism
2) Confidence 0.69 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.15 Pain Relevance 0.07
Intramyocellular fatty acid metabolites, such as diacylglycerol, have been postulated to activate a serine kinase cascade leading to increased serine phosphorylation of IRS-1.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of IRS-1
3) Confidence 0.69 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.90 Pain Relevance 0.08
Furthermore, tyrosine phosphorylation of IRS-1 was increased by 88% in Tg IRS-1 Ser?
Positive_regulation (increased) of Phosphorylation (phosphorylation) of IRS-1
4) Confidence 0.69 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.13 Pain Relevance 0.03
The data in the present study support the hypothesis that in vivo IRS-1 serine phosphorylation intereferes with IRS-1 tyrosine phosphorylation by the first three mechanisms, since we found increased insulin-stimulated IRS-1 tyrosine phosphorylation in the Tg IRS-1 Ser?
Positive_regulation (increased) of Phosphorylation (phosphorylation) of IRS-1 associated with hyperinsulinism
5) Confidence 0.69 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.15 Pain Relevance 0.07
To evaluate previous reports regarding increased serine phosphorylation on IRS-1 in skeletal muscle, we tested Ser307 and Ser612 residues using high-fat–fed mice and ob/ob mice.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of IRS-1 in skeletal muscle associated with obesity
6) Confidence 0.69 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.40 Pain Relevance 0
In summary, our study supports the hypothesis that high-fat diet–induced insulin resistance in skeletal muscle is mediated at least in part through increased serine phosphorylation of IRS-1.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of IRS-1 in skeletal muscle associated with insulin resistance
7) Confidence 0.69 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.68 Pain Relevance 0
We found no increase in IGF-1 receptor tyrosine phosphorylation or IRS1/2 associated p85 following resistance exercise and, from 30 minutes, p85 associated with IRS1/2 was reduced.
Neg (no) Positive_regulation (increase) of Phosphorylation (phosphorylation) of IRS1
8) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.07 Pain Relevance 0
However, it remains unknown whether increased IRS-1 serine phosphorylation plays a causative role in the pathogenesis of fat-induced insulin resistance in skeletal muscle or whether it is merely an associated phenomenon.
Spec (whether) Positive_regulation (increased) of Spec (whether) Phosphorylation (phosphorylation) of IRS-1 in fat associated with insulin resistance
9) Confidence 0.50 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.67 Pain Relevance 0.12
On the other hand, our data suggest that IRS-1 serine phosphorylation does not lead to increased IRS-1 degradation by activation of the ubiquitin-proteosome or suppressor of cytokine-signaling pathway, since IRS-1 protein expression was unchanged after 8 weeks of high-fat diet treatment (Fig. 1A).
Neg (not) Positive_regulation (lead) of Phosphorylation (phosphorylation) of IRS-1 in fat associated with cytokine
10) Confidence 0.50 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.21 Pain Relevance 0.08
The data in the present study support the hypothesis that in vivo IRS-1 serine phosphorylation intereferes with IRS-1 tyrosine phosphorylation by the first three mechanisms, since we found increased insulin-stimulated IRS-1 tyrosine phosphorylation in the Tg IRS-1 Ser?
Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of IRS-1 Ser associated with hyperinsulinism
11) Confidence 0.50 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.15 Pain Relevance 0.07
Our study demonstrates that serine phosphorylation on IRS-1 is a key molecular event in the pathogenesis of fat-induced insulin resistance in vivo.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of IRS-1 in fat associated with insulin resistance
12) Confidence 0.50 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.57 Pain Relevance 0.03
Increased serine phosphorylation of IRS-1 has been suggested to be responsible for this phenomenon (6), and, consistent with this hypothesis, recent studies have demonstrated hyperserine phosphorylation of IRS-1 on Ser302, Ser307, Ser612, and Ser636 in several insulin-resistant rodent models (7–10), as well as in lean insulin-resistant offspring of type 2 diabetic parents (11).
Positive_regulation (responsible) of Phosphorylation (phosphorylation) of IRS-1 associated with diabetes mellitus
13) Confidence 0.46 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.95 Pain Relevance 0.04
High-fat diet increased serine phosphorylation of IRS-1.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of IRS-1 in fat
14) Confidence 0.46 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.36 Pain Relevance 0
Acute resistance exercise did not increase either IGF-1 receptor phosphorylation or IRS1/2 associated p85.
Neg (not) Positive_regulation (increase) of Phosphorylation (phosphorylation) of IRS1
15) Confidence 0.36 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2905373 Disease Relevance 0.42 Pain Relevance 0
The increase in mTORC1 activity and PKB phosphorylation in the absence of IRS1/2 associated p85 is consistent with other models of contraction in which PKB is activated independent of any increase in tyrosine phosphorylation of the insulin receptor or IRS1 [49], [50].
Positive_regulation (increase) of Phosphorylation (phosphorylation) of IRS1
16) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0 Pain Relevance 0
Berberine only weakly stimulated the phosphorylation of AKT/PKB [21] and did not augment tyrosine phosphorylation of IR and IRS-1 in 3T3-L1 cells [22].
Neg (not) Positive_regulation (augment) of Phosphorylation (phosphorylation) of IRS-1 in 3T3-L1
17) Confidence 0.30 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952334 Disease Relevance 0.36 Pain Relevance 0
Accordingly, insulin-stimulated IRS-1 and AKT phosphorylation was inhibited by IL-6.
Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of IRS-1
18) Confidence 0.28 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.30 Pain Relevance 0.07
This effect is facilitated by up-regulation of tyrosine phosphorylation of IRS-1 (insulin receptor substrate) and enhanced bradykinin and NO activity (Krutzfeldt et al 2000; Shiuchi et al 2002).
Positive_regulation (regulation) of Phosphorylation (phosphorylation) of IRS-1 associated with bradykinin
19) Confidence 0.26 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 0.48 Pain Relevance 0.05
Thus, it is likely that reduction of ROS increases the phosphorylation and expression of IRS-1 through a reduction of JNK activity.
Positive_regulation (increases) of Phosphorylation (phosphorylation) of IRS-1
20) Confidence 0.25 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.13 Pain Relevance 0

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