INT230801

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Context Info
Confidence 0.28
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.12
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ren1) extracellular space (Ren1) extracellular region (Ren1)
intracellular (Ren1) response to stress (Ren1)
Anatomy Link Frequency
plasma 2
Ren1 (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 1 75.84 Quite High
Bioavailability 2 74.32 Quite High
Inflammation 8 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
bradykinin 3 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 31 98.24 Very High Very High Very High
Diabetes Mellitus 46 97.56 Very High Very High Very High
Coronary Artery Disease 30 89.04 High High
Proteinuria 21 83.68 Quite High
Disease 10 72.84 Quite High
Death 14 66.76 Quite High
Myocardial Infarction 13 65.76 Quite High
Stroke 7 64.84 Quite High
Disease Progression 1 64.72 Quite High
Albuminuria 2 55.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Likewise, ARBs increase plasma renin activity due to inhibition of the Ang II-renin release feedback loop [46].
Positive_regulation (increase) of Negative_regulation (inhibition) of renin in plasma
1) Confidence 0.28 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.77 Pain Relevance 0
The potential for renin inhibition as a target for blockade of the RAS has been considered for more than 30 years, as renin is the initial and rate limiting step in the RAS system (Skegg et al 1957).
Positive_regulation (potential) of Negative_regulation (inhibition) of renin
2) Confidence 0.18 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 0.36 Pain Relevance 0.08

General Comments

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