INT230805

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.46
First Reported 2007
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 23
Total Number 28
Disease Relevance 11.00
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Slc2a4) transport (Slc2a4) transmembrane transporter activity (Slc2a4)
plasma membrane (Slc2a4) transmembrane transport (Slc2a4) cytoplasm (Slc2a4)
Anatomy Link Frequency
skeletal muscle 4
plasma 3
muscle 3
myotubes 3
fat cells 3
Slc2a4 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 48 99.16 Very High Very High Very High
tolerance 266 98.58 Very High Very High Very High
cytokine 151 96.92 Very High Very High Very High
Hippocampus 15 93.60 High High
cerebral cortex 3 92.24 High High
bradykinin 4 88.40 High High
Inflammatory response 7 82.40 Quite High
Pain 3 69.92 Quite High
Inflammation 92 68.04 Quite High
Enkephalin 2 60.24 Quite High
Disease Link Frequency Relevance Heat
Insulin Resistance 491 99.78 Very High Very High Very High
Obesity 607 99.68 Very High Very High Very High
Aging 105 98.72 Very High Very High Very High
Impaired Glucose Tolerance 322 98.58 Very High Very High Very High
Cancer 165 93.12 High High
Diabetes Mellitus 609 92.76 High High
Necrosis 30 92.64 High High
Ovarian Cancer 59 89.80 High High
Wound Healing 3 86.40 High High
Hyperinsulinism 111 84.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-6 activates glucose uptake in a dose-dependent manner regardless of the time of treatment as a consequence of GLUT4 translocation to the plasma membrane in C2C12 myotubes and neonatal myotubes, in a similar fashion as reported in L6 cells and human skeletal muscle strips, respectively (12,35).
Localization (translocation) of GLUT4 in myotubes
1) Confidence 0.46 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.37 Pain Relevance 0.08
Glucose transport and GLUT4 translocation assays.
Localization (translocation) of GLUT4
2) Confidence 0.46 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0 Pain Relevance 0
Chronic exposure (24 h) to IL-6 impaired insulin-stimulated glucose uptake and GLUT4 translocation in both C2C12 and neonatal myotubes.
Localization (translocation) of GLUT4 in myotubes
3) Confidence 0.46 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.23 Pain Relevance 0.07
AKT phosphorylation was detected as early as after 5 min of insulin stimulation and remained increased for at least 30 min, the time required for optimal translocation of GLUT4 to the plasma membrane (supplementary Figure S1, which is available in an online appendix at http://dx.doi.org/10.2337/db07-1062).
Localization (translocation) of GLUT4 in appendix
4) Confidence 0.46 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.07 Pain Relevance 0.10
When examining GLUT4 translocation to the plasma membrane by Western blot (Fig. 2F) or indirect immunofluorescence (Fig. 2G), both insulin and IL-6 individually produced this effect, but when cells were pretreated with IL-6 for 24 h, insulin failed to translocate GLUT4.


Spec (examining) Localization (translocation) of GLUT4 in plasma
5) Confidence 0.46 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.14 Pain Relevance 0.04
When examining GLUT4 translocation to the plasma membrane by Western blot (Fig. 2F) or indirect immunofluorescence (Fig. 2G), both insulin and IL-6 individually produced this effect, but when cells were pretreated with IL-6 for 24 h, insulin failed to translocate GLUT4.


Neg (failed) Localization (translocate) of GLUT4 in plasma
6) Confidence 0.46 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.15 Pain Relevance 0.03
Two groups also reported that berberine was able to stimulate GLUT4 translocation [10, 34], but this activity was not observed by other groups [10, 22].
Localization (translocation) of GLUT4
7) Confidence 0.46 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952334 Disease Relevance 0.14 Pain Relevance 0
Physiologically, exercise enables GLUT4 to translocate into plasma membrane from vesicles through AMPK.
Localization (translocate) of GLUT4 in vesicles
8) Confidence 0.41 Published 2010 Journal PPAR Research Section Body Doc Link PMC2929615 Disease Relevance 0.33 Pain Relevance 0
The role of AMPK in exercise-induced glucose utilization is supported by the finding that treatment with aminoimidazole carboxamide ribonucleotide (AICAR), a direct AMPK activator, promoted glucose uptake, and GLUT4 translocation in skeletal muscle [45].
Localization (translocation) of GLUT4 in skeletal muscle
9) Confidence 0.41 Published 2010 Journal PPAR Research Section Body Doc Link PMC2929615 Disease Relevance 0.29 Pain Relevance 0
A dual effect on insulin action was observed when myotubes and mice were exposed to this cytokine: additive with short-term insulin (increased glucose uptake and systemic insulin sensitivity) but chronic exposure produced insulin resistance (impaired GLUT4 translocation to plasma membrane and defects in insulin signaling at the insulin receptor substrate 1 [IRS-1] level).
Localization (translocation) of GLUT4 in myotubes associated with insulin resistance and cytokine
10) Confidence 0.40 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2584126 Disease Relevance 0.40 Pain Relevance 0.15
This functional defect is partly due to a decrease in insulin-stimulated Akt activation and failure in the translocation of glucose transporter GLUT4 to the cell surface [11], [12], [13].
Localization (translocation) of GLUT4
11) Confidence 0.40 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0.76 Pain Relevance 0.10
In the presence of insulin, IRAP and GLUT4 translocate to the cell membrane where GLUT4 mediates glucose uptake.
Localization (translocate) of GLUT4
12) Confidence 0.37 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604899 Disease Relevance 0.09 Pain Relevance 0.06
Exercise-induced, contraction-mediated GLUT4 translocation to the muscle membrane is independent of insulin and occurs via an alternative mechanism (reviewed in [58]).
Localization (translocation) of GLUT4 in muscle
13) Confidence 0.19 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3010636 Disease Relevance 0.65 Pain Relevance 0.08
Injection of this IRAP domain into fat cells results in the translocation of GLUT4 vesicles to the plasma membrane [28].
Localization (translocation) of GLUT4 in vesicles associated with obesity
14) Confidence 0.19 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604898 Disease Relevance 0.16 Pain Relevance 0
GLUT4 is also found in the pituitary and the hypothalamus.
Localization (found) of GLUT4 in pituitary
15) Confidence 0.17 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.08 Pain Relevance 0.13
Serine kinases impede insulin signaling by reducing IRS phosphorylation [64, 65, 72] which leads to a decline in insulin-stimulated GLUT4 translocation and impaired skeletal muscle glucose uptake [64, 65].

3.4.

Localization (translocation) of GLUT4 in skeletal muscle
16) Confidence 0.17 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3010636 Disease Relevance 0.96 Pain Relevance 0.03
Insulin's effects on peripheral tissues (i.e., skeletal muscle, adipose tissue) involve a complex framework of signaling pathways that result in the translocation of GLUT4 transporters to the cell surface, which are responsible for the transport of glucose across the plasma membrane into the target cell [53].
Localization (translocation) of GLUT4 in skeletal muscle associated with obesity
17) Confidence 0.17 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3010636 Disease Relevance 1.08 Pain Relevance 0.08
Importantly, older adults with diminished glucose tolerance do not demonstrate a decline in exercise-induced contractile-mediated GLUT4 translocation [59].

3.2.

Localization (translocation) of GLUT4 associated with tolerance and impaired glucose tolerance
18) Confidence 0.17 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3010636 Disease Relevance 0.86 Pain Relevance 0.08
At least two discrete signalling pathways have been implicated in insulin-regulated GLUT-4 translocation.
Localization (translocation) of GLUT-4
19) Confidence 0.14 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.29 Pain Relevance 0
The rate-limiting step at which insulin stimulates uptake of glucose in fat is the translocation of GLUT-4 to the plasma membrane [139].
Localization (translocation) of GLUT-4 in plasma
20) Confidence 0.14 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.31 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox