INT230806

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Context Info
Confidence 0.55
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 15
Disease Relevance 16.08
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Agt) extracellular matrix organization (Agt)
Anatomy Link Frequency
liver 4
blood 2
fat 2
kidney 2
Agt (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 100 100.00 Very High Very High Very High
cytokine 29 100.00 Very High Very High Very High
fibrosis 4 88.08 High High
substance P 4 86.12 High High
bradykinin 19 85.48 High High
antagonist 28 78.40 Quite High
agonist 17 76.16 Quite High
Bioavailability 3 43.24 Quite Low
Potency 9 42.16 Quite Low
Inflammatory response 7 32.04 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 103 100.00 Very High Very High Very High
Metastasis 160 99.92 Very High Very High Very High
Infection 148 99.72 Very High Very High Very High
Colon Cancer 164 99.58 Very High Very High Very High
Pre-eclampsia 230 99.54 Very High Very High Very High
Cytomegalovirus Infection 192 99.52 Very High Very High Very High
Hyperglycemia 12 99.34 Very High Very High Very High
Hypertension 161 98.96 Very High Very High Very High
Renal Disease 18 98.76 Very High Very High Very High
Cancer 151 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The antihypertensive effects of APA and candesartan were maintained by increasing the dose with advancing gestation, suggesting that AngII synthesis increases over time in pregnant SHRs.
Positive_regulation (increases) of Gene_expression (synthesis) of AngII
1) Confidence 0.55 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.30 Pain Relevance 0
Taken together, these findings present a treatment dilemma since the increased synthesis of AngII by the fetus significantly contributes to preeclampsia; while vasoconstriction of the fetoplacental circulation may be of primary importance in preeclampsia [70].
Positive_regulation (increased) of Gene_expression (synthesis) of AngII associated with increased venous pressure under development and pre-eclampsia
2) Confidence 0.55 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 1.05 Pain Relevance 0
It is likely that increased APA and P-LAP activity in maternal sera before, and immediately after, the appearance of preeclampsia is in response to the increased production of AngII/AVP from the fetus.
Positive_regulation (increased) of Gene_expression (production) of AngII associated with pre-eclampsia
3) Confidence 0.55 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.63 Pain Relevance 0.10
The activation of the renal renin angiotensin system (RAS), characterized by elevated ACE expression and increased local angiotensin (Ang) II production, has been found in many human kidney diseases [3].
Positive_regulation (increased) of Gene_expression (production) of angiotensin in kidney associated with renal disease
4) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672164 Disease Relevance 0.89 Pain Relevance 0.17
While they block the AT1 receptor and negative many of the ill effects of Ang II, there is a paucity of information about the long term effects of elevated Ang II levels on the AT2 receptors.
Positive_regulation (elevated) of Gene_expression (levels) of Ang II
5) Confidence 0.40 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 0.39 Pain Relevance 0.13
Likewise, both hyperglycemia and insulin activate the RAS by increasing expression of angiotensinogen, Ang II, and regulation and activity of the angiotensin type 1 (AT1) receptor.
Positive_regulation (increasing) of Gene_expression (expression) of Ang II associated with hyperglycemia
6) Confidence 0.40 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 1.09 Pain Relevance 0.04
Likewise, both hyperglycemia and insulin activate the RAS by increasing expression of angiotensinogen, Ang II, and regulation and activity of the angiotensin type 1 (AT1) receptor.
Positive_regulation (increasing) of Gene_expression (expression) of angiotensinogen associated with hyperglycemia
7) Confidence 0.40 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 1.09 Pain Relevance 0.04
It is likely that increased APA and P-LAP activity in maternal sera before, and immediately after, the appearance of preeclampsia is in response to the increased production of AngII/AVP from the fetus.
Positive_regulation (increased) of Gene_expression (production) of AngII associated with pre-eclampsia
8) Confidence 0.40 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.63 Pain Relevance 0.10
Although increased circulating levels of AngII in APA KO mice result in hypertension, it may not stimulate the synthesis of growth factor-?
Positive_regulation (increased) of Gene_expression (levels) of AngII associated with hypertension
9) Confidence 0.37 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.53 Pain Relevance 0
These results also imply that much of the ANG II available to drive growth of CRC liver metastases is derived from local host production of angiotensinogen, which is then converted to ANG II via high ACE expression in tumors.
Positive_regulation (derived) of Gene_expression (production) of angiotensinogen in liver associated with cancer, colon cancer and metastasis
10) Confidence 0.29 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.83 Pain Relevance 0
These results also imply that much of the ANG II available to drive growth of CRC liver metastases is derived from local host production of angiotensinogen, which is then converted to ANG II via high ACE expression in tumors.
Positive_regulation (converted) of Gene_expression (production) of angiotensinogen in liver associated with cancer, colon cancer and metastasis
11) Confidence 0.29 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.82 Pain Relevance 0
A persistent CMV infection of EC and an increased pro-inflammatory cytokine expression, including renin and AngII, may underlie the molecular mechanism by which CMV infection induced an increase of blood pressure.


Positive_regulation (increased) of Gene_expression (expression) of AngII in blood associated with pressure and volume under development, inflammation, cytomegalovirus infection, infection and cytokine
12) Confidence 0.28 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 3.12 Pain Relevance 0.16
Interestingly, increased production of angiotensinogen by intra-abdominal fat appears to explain the high circulating levels of this peptide observed in dietary obesity (Boustany et al 2004).
Positive_regulation (increased) of Gene_expression (production) of angiotensinogen in fat associated with metabolic syndrome
13) Confidence 0.13 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464748 Disease Relevance 1.39 Pain Relevance 0.03
It is also possible that decreased Ca2+ influx upon prestimulation with angiotensin results, in part, from cross-desensitization of TRPV4.

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Positive_regulation (prestimulation) of Gene_expression (results) of angiotensin
14) Confidence 0.11 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0.07
We have previously shown an increased expression of leptin, PAI-1 and angiotensinogen mRNA in offspring of dams underfed during gestation but only when catch-up growth had occurred [13], [14].
Positive_regulation (increased) of Gene_expression (expression) of angiotensinogen mRNA
15) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2936567 Disease Relevance 1.27 Pain Relevance 0

General Comments

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