INT230808

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Context Info
Confidence 0.40
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 5.42
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Slc2a4) transport (Slc2a4) transmembrane transporter activity (Slc2a4)
plasma membrane (Slc2a4) transmembrane transport (Slc2a4) cytoplasm (Slc2a4)
Anatomy Link Frequency
skeletal muscle 7
vesicles 4
muscle 3
fat cells 3
myotubes 2
Slc2a4 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 13 99.16 Very High Very High Very High
tolerance 110 91.96 High High
bradykinin 4 88.40 High High
cytokine 46 81.44 Quite High
ischemia 5 46.60 Quite Low
Eae 1 42.92 Quite Low
Inflammation 42 28.60 Quite Low
amygdala 1 17.32 Low Low
Hippocampus 2 16.92 Low Low
metalloproteinase 6 8.96 Low Low
Disease Link Frequency Relevance Heat
Obesity 247 99.98 Very High Very High Very High
Insulin Resistance 184 94.96 High High
Diabetes Mellitus 269 93.08 High High
Impaired Glucose Tolerance 137 91.96 High High
Ovarian Cancer 59 90.24 High High
Cancer 145 89.52 High High
Targeted Disruption 187 84.72 Quite High
Adenocarcinoma 1 83.76 Quite High
Aging 39 80.40 Quite High
Apoptosis 14 70.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AKT phosphorylation was detected as early as after 5 min of insulin stimulation and remained increased for at least 30 min, the time required for optimal translocation of GLUT4 to the plasma membrane (supplementary Figure S1, which is available in an online appendix at http://dx.doi.org/10.2337/db07-1062).
Positive_regulation (required) of Localization (translocation) of GLUT4 in appendix
1) Confidence 0.40 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.07 Pain Relevance 0.10
Two groups also reported that berberine was able to stimulate GLUT4 translocation [10, 34], but this activity was not observed by other groups [10, 22].
Positive_regulation (stimulate) of Localization (translocation) of GLUT4
2) Confidence 0.30 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952334 Disease Relevance 0.14 Pain Relevance 0
IL-6 activates glucose uptake in a dose-dependent manner regardless of the time of treatment as a consequence of GLUT4 translocation to the plasma membrane in C2C12 myotubes and neonatal myotubes, in a similar fashion as reported in L6 cells and human skeletal muscle strips, respectively (12,35).
Positive_regulation (consequence) of Localization (translocation) of GLUT4 in myotubes
3) Confidence 0.29 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.37 Pain Relevance 0.08
The role of AMPK in exercise-induced glucose utilization is supported by the finding that treatment with aminoimidazole carboxamide ribonucleotide (AICAR), a direct AMPK activator, promoted glucose uptake, and GLUT4 translocation in skeletal muscle [45].
Positive_regulation (promoted) of Localization (translocation) of GLUT4 in skeletal muscle
4) Confidence 0.24 Published 2010 Journal PPAR Research Section Body Doc Link PMC2929615 Disease Relevance 0.29 Pain Relevance 0
Physiologically, exercise enables GLUT4 to translocate into plasma membrane from vesicles through AMPK.
Positive_regulation (enables) of Localization (translocate) of GLUT4 in vesicles
5) Confidence 0.24 Published 2010 Journal PPAR Research Section Body Doc Link PMC2929615 Disease Relevance 0.33 Pain Relevance 0
Injection of this IRAP domain into fat cells results in the translocation of GLUT4 vesicles to the plasma membrane [28].
Positive_regulation (results) of Localization (translocation) of GLUT4 in vesicles associated with obesity
6) Confidence 0.12 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604898 Disease Relevance 0.16 Pain Relevance 0
Insulin's effects on peripheral tissues (i.e., skeletal muscle, adipose tissue) involve a complex framework of signaling pathways that result in the translocation of GLUT4 transporters to the cell surface, which are responsible for the transport of glucose across the plasma membrane into the target cell [53].
Positive_regulation (result) of Localization (translocation) of GLUT4 in skeletal muscle associated with obesity
7) Confidence 0.11 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3010636 Disease Relevance 1.09 Pain Relevance 0.08
Two important targets of PI3K in muscle and fat cells that have been shown to have a role in insulin-stimulated GLUT-4 translocation are the AKT and the protein kinase C (PKC).
Positive_regulation (stimulated) of Localization (translocation) of GLUT-4 in fat cells associated with kinase c and obesity
8) Confidence 0.08 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.16 Pain Relevance 0.10
The second putative signalling pathway that has been shown to have a role in insulin-stimulated GLUT-4 translocation operates independently of PI3K and involves a dimeric complex that comprises c-Cbl and the c-Cbl-associated protein CAP.
Positive_regulation (stimulated) of Localization (translocation) of GLUT-4
9) Confidence 0.08 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.22 Pain Relevance 0.13
The improved insulin sensitivity seen with ACE inhibitors appears to results in an increased glucose uptake by skeletal muscles via enhanced synthesis and translocation of the glucose transporter 4 protein to the cell surface.
Positive_regulation (enhanced) of Localization (translocation) of glucose transporter 4 protein in skeletal muscles
10) Confidence 0.06 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 0.50 Pain Relevance 0.04
Metformin may preferentially increase peripheral glucose uptake in skeletal muscle, as administration increases AMPK activity in skeletal muscle [132] and stimulates translocation of muscle GLUT-4 [133].
Positive_regulation (stimulates) of Localization (translocation) of GLUT-4 in muscle
11) Confidence 0.05 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2825545 Disease Relevance 0.83 Pain Relevance 0
Insulin's effects on peripheral tissues (i.e., skeletal muscle, adipose tissue) involve a complex framework of signaling pathways that result in the translocation of GLUT4 transporters to the cell surface, which are responsible for the transport of glucose across the plasma membrane into the target cell [53].
Positive_regulation (result) of in adipose tissue Localization (translocation) of GLUT4 in skeletal muscle associated with obesity
12) Confidence 0.04 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3010636 Disease Relevance 1.09 Pain Relevance 0.08
Two important targets of PI3K in muscle and fat cells that have been shown to have a role in insulin-stimulated GLUT-4 translocation are the AKT and the protein kinase C (PKC).
Positive_regulation (stimulated) of in muscle Localization (translocation) of GLUT-4 in fat cells associated with kinase c and obesity
13) Confidence 0.03 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.16 Pain Relevance 0.10

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