INT230810

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Context Info
Confidence 0.69
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 59
Total Number 59
Disease Relevance 41.15
Pain Relevance 4.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) extracellular region (Ins1) carbohydrate metabolic process (Ins1)
cytoplasm (Ins1)
Anatomy Link Frequency
muscle 4
skeletal muscle 4
liver 3
adipose tissue 3
fat 2
Ins1 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 216 100.00 Very High Very High Very High
cytokine 208 99.44 Very High Very High Very High
bradykinin 3 98.64 Very High Very High Very High
Inflammation 440 95.32 Very High Very High Very High
Kinase C 54 92.32 High High
aspirin 3 92.16 High High
agonist 216 91.72 High High
cerebral cortex 3 89.68 High High
Central nervous system 18 89.40 High High
Hippocampus 14 87.76 High High
Disease Link Frequency Relevance Heat
Insulin Resistance 1163 100.00 Very High Very High Very High
Hyperinsulinism 88 100.00 Very High Very High Very High
Shock 646 99.72 Very High Very High Very High
Obesity 978 99.40 Very High Very High Very High
Targeted Disruption 466 99.24 Very High Very High Very High
Diabetes Mellitus 520 98.76 Very High Very High Very High
Impaired Glucose Tolerance 176 96.72 Very High Very High Very High
Dislocations 16 96.08 Very High Very High Very High
INFLAMMATION 475 95.32 Very High Very High Very High
Acromegaly 108 94.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, it is possible that the glucose and insulin response of PKBser473 phosphorylation follow different kinetics in response to a continuous infusion and a bolus administration.
Phosphorylation (phosphorylation) of insulin
1) Confidence 0.69 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2852377 Disease Relevance 0.49 Pain Relevance 0
Insulin stimulated phosphorylation of PKB at serine 473 was measured and corrected for total PKB.


Phosphorylation (phosphorylation) of Insulin
2) Confidence 0.68 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2852377 Disease Relevance 0.10 Pain Relevance 0.04
Analysis of insulin induced phosphorylation of PKBser473 in muscle confirmed that all high fat diets induce peripheral insulin resistance (figure 4B).
Phosphorylation (phosphorylation) of insulin in fat associated with insulin resistance
3) Confidence 0.68 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2852377 Disease Relevance 0.45 Pain Relevance 0
This tissue-specific pattern of reduced insulin sensitivity was confirmed by similar impairment in insulin-induced phosphorylation of PKBser473 in both liver and skeletal muscle.


Phosphorylation (phosphorylation) of insulin in skeletal muscle
4) Confidence 0.53 Published 2010 Journal Nutr Metab (Lond) Section Abstract Doc Link PMC2852377 Disease Relevance 0.24 Pain Relevance 0
In liver, the insulin-induced stimulation of PKBser473 phosphorylation was identical in chow and low stearate HFP fed mice (3.3 ± 0.6 and 2.9 ± 0.4 fold, respectively) but severely impaired in stearate-rich HFL and HFPS fed mice (1.1 ± 0.1 and 1.1 ± 0.4 fold, respectively; p < 0.01 and p < 0.05 compared to HFP fed mice) (figure 3A).
Phosphorylation (phosphorylation) of insulin in HFL
5) Confidence 0.53 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2852377 Disease Relevance 0.47 Pain Relevance 0
However, it has been demonstrated that insulin resistance associated with obesity largely stems from posttranslational modifications of insulin signaling proteins, such as inhibitory serine phosphorylation of the insulin receptor or its downstream signaling mediators [33].
Phosphorylation (phosphorylation) of insulin in stems associated with obesity and insulin resistance
6) Confidence 0.38 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.23 Pain Relevance 0.22
Two-week high fat feeding induced hyperinsulinemia and severe hepatic and skeletal muscle insulin resistance in WT but not 12/15LO KO mice. 12/15LO KO mice exhibited significantly greater insulin-stimulated skeletal muscle Akt phosphorylation after HFD, compared to WT mice, corresponding to their greater insulin sensitivity.
Phosphorylation (phosphorylation) of insulin in skeletal muscle associated with targeted disruption, hyperinsulinism and insulin resistance
7) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2746280 Disease Relevance 2.07 Pain Relevance 0.26
However, the absolute level of insulin-stimulated Akt phosphorylation and the insulin-stimulated fold change in Akt phosphorylation were both significantly greater, two- and three-fold, respectively, in 12/15LO KO mice compared to WT mice.
Phosphorylation (phosphorylation) of insulin associated with targeted disruption
8) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2746280 Disease Relevance 1.06 Pain Relevance 0.03
In order to assess the effects of 12/15LO KO on insulin signal transduction in skeletal muscle from mice fed HFD, we examined acute insulin-activated Akt phosphorylation in a separate group of mice.
Phosphorylation (phosphorylation) of insulin in skeletal muscle associated with targeted disruption
9) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2746280 Disease Relevance 0.99 Pain Relevance 0
However, the absolute level of insulin-stimulated Akt phosphorylation and the insulin-stimulated fold change in Akt phosphorylation were both significantly greater, two- and three-fold, respectively, in 12/15LO KO mice compared to WT mice.
Phosphorylation (phosphorylation) of insulin associated with targeted disruption
10) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2746280 Disease Relevance 1.11 Pain Relevance 0.08
Diminished insulin-activated Akt phosphorylation in muscle from HFD-fed WT compared to 12/15LO KO mice
Phosphorylation (phosphorylation) of insulin in muscle associated with targeted disruption
11) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2746280 Disease Relevance 1.02 Pain Relevance 0
Insulin-stimulated Akt phosphorylation in muscle tissue from HFD-fed mice was significantly greater in 12/15LO KO mice than in WT mice.


Phosphorylation (phosphorylation) of Insulin in muscle tissue associated with targeted disruption
12) Confidence 0.34 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2746280 Disease Relevance 1.52 Pain Relevance 0.24
MES (12 V)+mild HS treatment of high fat-fed mice also increased the phosphorylation of insulin receptor ?
Phosphorylation (phosphorylation) of insulin in fat associated with shock
13) Confidence 0.31 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2603588 Disease Relevance 1.27 Pain Relevance 0
To confirm whether HS+MES promotes insulin receptor phosphorylation, which initiates insulin action by phosphorylating multiple intracellular substrates, we determined the phosphorylation status of IR?
Phosphorylation (phosphorylation) of insulin associated with shock
14) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 1.33 Pain Relevance 0
Here we show that 10-min treatment with MES at 5 V (0.1 ms pulse duration) together with HS at 42°C increased the phosphorylation of insulin signaling molecules such as insulin receptor substrate (IRS) and Akt in HepG2 cells maintained in high-glucose medium.
Phosphorylation (phosphorylation) of insulin associated with shock
15) Confidence 0.31 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2603588 Disease Relevance 1.15 Pain Relevance 0
The effect produced by GW3965 on glucose uptake was parallel to a downregulation of socs3 and ptp1b gene expression and to the recovery of insulin phosphorylation of AKT (Fig. 7).
Phosphorylation (phosphorylation) of insulin
16) Confidence 0.25 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.45 Pain Relevance 0.29
AS160 was phosphorylated by IL-6 and insulin individually, and when combined, an additive effect was produced at 3 h of IL-6 treatment.
Phosphorylation (phosphorylated) of insulin
17) Confidence 0.24 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.12 Pain Relevance 0.10
Insulin-stimulated Akt phosphorylation has also been observed to be up-regulated in Hsp72 transgenic mice [24].
Phosphorylation (phosphorylation) of Insulin associated with targeted disruption
18) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0.40 Pain Relevance 0
Consequently, this treatment enhanced the insulin-stimulated Akt phosphorylation in HepG2 cells exposed to high glucose similar to Hsp72 overexpression (Fig. 9D,E).
Phosphorylation (phosphorylation) of insulin
19) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0.78 Pain Relevance 0
Consistent with previous report, HepG2 cells exposed to high glucose concentration (25 mM) exhibited reduced insulin-stimulated Akt phosphorylation (Fig. 8A, [34]).
Phosphorylation (phosphorylation) of insulin
20) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0.68 Pain Relevance 0

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