INT230859

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Context Info
Confidence 0.14
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.00
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (THBD) plasma membrane (THBD) embryo development (THBD)
Anatomy Link Frequency
blood 2
THBD (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 20 91.12 High High
imagery 3 64.08 Quite High
Angina 3 20.88 Low Low
tolerance 20 5.00 Very Low Very Low Very Low
Kinase C 8 5.00 Very Low Very Low Very Low
bradykinin 4 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
Bioavailability 3 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
positron emission tomography 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 37 99.96 Very High Very High Very High
Thrombosis 1 99.62 Very High Very High Very High
Atherosclerosis 34 97.80 Very High Very High Very High
Renal Disease 4 96.04 Very High Very High Very High
Diabetes Mellitus 214 92.84 High High
INFLAMMATION 19 91.12 High High
Diabetes Mellitus-type I 2 88.24 High High
Adhesions 19 86.16 High High
Obesity 14 65.48 Quite High
Cardiovascular Disease 18 61.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A variety of markers indicate endothelial dysfunction including: poor EC-dependent vasodilation, increased blood levels of von Willebrand factor (vWF), thrombomodulin, selectin, PAI-1, type IV collagen and t-PA were demonstrated in this patients population (Yaqoob et al 1993; Dosquet et al 1994; Myrup et al 1994; Makimattila et al 1996; Huszka et al 1997; Cosentino and Luscher 1998; Elhadd et al 1998; Malamitsi et al 1998; Huvers et al 1999).
Positive_regulation (increased) of Gene_expression (levels) of thrombomodulin in blood associated with increased venous pressure under development
1) Confidence 0.14 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350146 Disease Relevance 1.62 Pain Relevance 0
Moreover, pitavastatin is reported to have an inhibitory effect on plasminogen activator inihibitor-1 (PAI-1)22,23 and tissue factor (TF)23 which are important factors in thrombosis formation, and to induce tissue plasminogen activator (t-PA)23 and thrombomodulin (TM) expression.22,24 Therefore, pitavastatin is expected to exert its anti-atherosclerotic effect via various mechanisms.
Positive_regulation (induce) of Gene_expression (expression.22,24) of thrombomodulin associated with atherosclerosis and thrombosis
2) Confidence 0.10 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788597 Disease Relevance 0.37 Pain Relevance 0.08

General Comments

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