INT230861

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Context Info
Confidence 0.35
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.65
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOS1) oxidoreductase activity (NOS1) cytoskeleton (NOS1)
cytoplasm (NOS1)
NOS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 39 100.00 Very High Very High Very High
gABA 28 100.00 Very High Very High Very High
nMDA receptor 30 54.04 Quite High
Inflammation 17 50.00 Quite Low
Hippocampus 27 41.68 Quite Low
long-term potentiation 10 31.28 Quite Low
tolerance 20 14.96 Low Low
cytokine 6 9.24 Low Low
5HT 13 5.00 Very Low Very Low Very Low
Kinase C 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 6 98.24 Very High Very High Very High
Stress 104 97.92 Very High Very High Very High
Injury 27 92.80 High High
Post-traumatic Stress Disorder 88 77.20 Quite High
Dyslipidemia /

Combined Dyslipidemia

3 74.32 Quite High
Insulin Resistance 38 72.60 Quite High
Hypertension 22 69.04 Quite High
Atherosclerosis 25 67.20 Quite High
Adhesions 18 63.48 Quite High
Hyperinsulinism 7 53.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NO via nNOS is increased after acute stress (Krukoff and Khalilli 1997; De Oliviera et al 2000) where NO acts predominantly as a neuromodulator by decreasing glutamate release, NO release, NOS activity, and increasing GABA release (see Figure 1 for detailed description) (Harvey 1996; Prast and Philippu 2001).
Negative_regulation (decreasing) of Localization (release) of NOS associated with stress, gaba and glutamate
1) Confidence 0.35 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.86 Pain Relevance 0.19
HDL cholesterol can prevent the oxidized LDL–mediated decrease in cholesterol in caveolae, prevent the translocation of endothelial NOS and caveol in from caveolae, and prevent the decrease in responsiveness to acetylcholine (Uittenbogaard et al 2000).
Negative_regulation (prevent) of Localization (translocation) of NOS associated with disorder of lipid metabolism
2) Confidence 0.14 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350146 Disease Relevance 0.71 Pain Relevance 0

General Comments

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