INT230866

Context Info Confidence 0.28 First Reported 2007 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.37 Pain Relevance 0.07

cytosol (PIK3CG) plasma membrane (PIK3CG) cytoplasm (PIK3CG)

Anatomy Link Frequency endothelial cells 2 PIK3CG (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 16 75.44 tolerance 20 55.20 headache 4 32.52 Kinase C 8 5.00 positron emission tomography 6 5.00 Bioavailability 4 5.00 bradykinin 4 5.00 adenocard 3 5.00 peripheral neuropathy 2 5.00 agonist 2 5.00

Disease Link Frequency Relevance Heat Insulin Resistance 38 94.56 Metabolic Syndrome 23 93.44 Disorder Of Lipid Metabolism 6 86.80 Pressure And Volume Under Development 4 85.76 Adhesions 21 84.92 Fever 5 84.84 Hypertension 24 81.20 Cancer 39 80.88 Malabsorption Syndromes 6 79.84 INFLAMMATION 16 75.44

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

XL765, a dual PI3K and mTOR inhibitor

Negative_regulation (inhibitor) of Gene_expression (XL765) of PI3K

1) Confidence 0.28 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2647552 Disease Relevance 0.54 Pain Relevance 0

PPAR- is expressed in endothelial cells, and its ligands have been reported to enhance NO production, possibly by stimulating the PI3K pathway and hence expression of eNOS (Kim et al 2002).

Negative_regulation (stimulating) of Gene_expression (expression) of PI3K in endothelial cells

2) Confidence 0.11 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350146 Disease Relevance 0.84 Pain Relevance 0.07

General Comments

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