INT230866

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Context Info
Confidence 0.28
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.37
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PIK3CG) plasma membrane (PIK3CG) cytoplasm (PIK3CG)
Anatomy Link Frequency
endothelial cells 2
PIK3CG (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 16 75.44 Quite High
tolerance 20 55.20 Quite High
headache 4 32.52 Quite Low
Kinase C 8 5.00 Very Low Very Low Very Low
positron emission tomography 6 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
bradykinin 4 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
peripheral neuropathy 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 38 94.56 High High
Metabolic Syndrome 23 93.44 High High
Disorder Of Lipid Metabolism 6 86.80 High High
Pressure And Volume Under Development 4 85.76 High High
Adhesions 21 84.92 Quite High
Fever 5 84.84 Quite High
Hypertension 24 81.20 Quite High
Cancer 39 80.88 Quite High
Malabsorption Syndromes 6 79.84 Quite High
INFLAMMATION 16 75.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
XL765, a dual PI3K and mTOR inhibitor
Negative_regulation (inhibitor) of Gene_expression (XL765) of PI3K
1) Confidence 0.28 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2647552 Disease Relevance 0.54 Pain Relevance 0
PPAR- is expressed in endothelial cells, and its ligands have been reported to enhance NO production, possibly by stimulating the PI3K pathway and hence expression of eNOS (Kim et al 2002).
Negative_regulation (stimulating) of Gene_expression (expression) of PI3K in endothelial cells
2) Confidence 0.11 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350146 Disease Relevance 0.84 Pain Relevance 0.07

General Comments

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