INT230874

Context Info Confidence 0.23 First Reported 2007 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 4 Total Number 5 Disease Relevance 1.88 Pain Relevance 0.16

extracellular region (C9) plasma membrane (C9)

Anatomy Link Frequency neural tube 1 MCs 1 C9 (Mus musculus)

Pain Link Frequency Relevance Heat Spinal cord 2 92.28 Inflammation 74 73.12 Pain 1 72.64 substantia gelatinosa 2 49.84 cytokine 8 5.00 ischemia 8 5.00 Morphine 6 5.00 Inflammatory stimuli 6 5.00 anesthesia 4 5.00 alcohol 4 5.00

Disease Link Frequency Relevance Heat Death 74 97.64 Apoptosis 62 93.52 Overdose 8 92.32 Myocardial Infarction 26 85.60 Sudden Death 6 84.52 Necrosis 24 81.64 Stress 56 81.60 Myositis 84 73.12 Pain 1 72.64 INFLAMMATION 66 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The presence of intracellular positive staining for C9 was occasionally observed among either CHOP-negative (Figure 1h, double arrowhead) or CHOP-positive regenerating myofibers (data not shown).

Neg (negative) Gene_expression (negative) of C9

1) Confidence 0.23 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.21 Pain Relevance 0.04

It is also known that Hoxc6, c8, c9, d9, and d10 gene expression is restricted to postmitotic cells in the ventral region of the neural tube at E12.5 [40]–[43].

Gene_expression (expression) of c9 in neural tube

2) Confidence 0.21 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527684 Disease Relevance 0.07 Pain Relevance 0.12

Reactive fibers displayed also intense staining for both calreticulin and Grp94 (data not shown) and were often positive for C9 (arrows in Additional file 4) and ubiquitin (data not shown).

Gene_expression (positive) of C9

3) Confidence 0.20 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.12 Pain Relevance 0

The distribution profile of cardiac infiltrated-MCs and production patterns of TNF and C9 (necrotic marker) were investigated immunohistochemically.

Gene_expression (production) of C9 in MCs

4) Confidence 0.09 Published 2007 Journal Vascular Health and Risk Management Section Abstract Doc Link PMC2350147 Disease Relevance 1.41 Pain Relevance 0

The sections were counter-stained with light green in the case of MCs subtypes and C9, or Mayer’s Hematoxylin, for TNF-?

Gene_expression (subtypes) of C9

5) Confidence 0.08 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350147 Disease Relevance 0.06 Pain Relevance 0

General Comments

This test has worked.