INT23088

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Context Info
Confidence 0.79
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 9.85
Pain Relevance 3.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnf) extracellular space (Tnf) extracellular region (Tnf)
plasma membrane (Tnf) intracellular (Tnf) extracellular matrix organization (Tnf)
Anatomy Link Frequency
spinal cord 3
plasma 1
brain 1
dorsal horn 1
nucleus pulposus 1
Tnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 52 100.00 Very High Very High Very High
Spinal cord 14 99.64 Very High Very High Very High
Cancer pain 10 99.54 Very High Very High Very High
Spontaneous pain 5 99.06 Very High Very High Very High
Brush evoked pain 4 98.64 Very High Very High Very High
Sciatica 2 97.60 Very High Very High Very High
Eae 50 96.72 Very High Very High Very High
Thermal hyperalgesia 9 96.20 Very High Very High Very High
allodynia 11 95.20 Very High Very High Very High
Neuropathic pain 24 94.32 High High
Disease Link Frequency Relevance Heat
Necrosis 24 100.00 Very High Very High Very High
Cancer 163 99.98 Very High Very High Very High
Amputation 42 99.76 Very High Very High Very High
Cancer Pain 10 99.54 Very High Very High Very High
Pain 12 99.06 Very High Very High Very High
Neuropathic Pain 44 98.64 Very High Very High Very High
Syndrome 19 97.88 Very High Very High Very High
Nerve Root Compression 2 97.60 Very High Very High Very High
Injury 70 96.72 Very High Very High Very High
Hyperalgesia 16 96.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, our results indicate that bilateral increase in the level of TNF-?
Phosphorylation (level) of TNF
1) Confidence 0.79 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2828436 Disease Relevance 0.98 Pain Relevance 0.68
The advent of TNF-?
Phosphorylation (advent) of TNF
2) Confidence 0.79 Published 2007 Journal Curr Treat Options Oncol Section Body Doc Link PMC2781100 Disease Relevance 1.38 Pain Relevance 0.05
In magnetic resonance spectrometry studies, we have shown that shutdown of the tumor is virtually complete within 16 hours after the perfusion, confirming the likelihood of TNF-?
Phosphorylation (likelihood) of TNF associated with cancer
3) Confidence 0.79 Published 2007 Journal Curr Treat Options Oncol Section Body Doc Link PMC2781100 Disease Relevance 0.63 Pain Relevance 0
At 2 µg doses of TNF-?
Phosphorylation (doses) of TNF
4) Confidence 0.79 Published 2007 Journal Curr Treat Options Oncol Section Body Doc Link PMC2781100 Disease Relevance 0.98 Pain Relevance 0
TNF-alpha and phosphorylation of ERK in DRG and spinal cord: insights into mechanisms of sciatica.
Phosphorylation (phosphorylation) of TNF-alpha in spinal cord associated with sciatica and spinal cord
5) Confidence 0.75 Published 2006 Journal Spine Section Title Doc Link 16508545 Disease Relevance 0.10 Pain Relevance 0.15
Fifteen hours later, tumor necrosis factor alpha, interleukin 1beta, p38 MAPK, and phosphorylated p38 MAPK were measured by enzyme-linked immunosorbent assay in DRGs and in the spinal cord.
Phosphorylation (phosphorylated) of tumor necrosis factor alpha in spinal cord
6) Confidence 0.69 Published 2006 Journal Anesthesiology Section Body Doc Link 16810005 Disease Relevance 0 Pain Relevance 0
STUDY DESIGN: This study tested the hypothesis that the 17-kDa form of tumor necrosis factor-alpha is the pathophysiologic agent expressed by herniated nucleus pulposus in vivo that is primarily responsible for the histologic and behavioral manifestations of experimental sciatica associated with herniated lumbar discs.
Phosphorylation (form) of tumor necrosis factor-alpha in nucleus pulposus associated with necrosis, cancer and sciatica
7) Confidence 0.63 Published 2000 Journal Spine Section Abstract Doc Link 11145807 Disease Relevance 0.44 Pain Relevance 0.09
TNF-alpha down-regulates perilipin but promotes its phosphorylation during lipolysis stimulation; these actions are efficiently reversed by salicylate.
Phosphorylation (phosphorylation) of TNF-alpha
8) Confidence 0.57 Published 2008 Journal Mol. Pharmacol. Section Abstract Doc Link 17911533 Disease Relevance 0.66 Pain Relevance 0.13
Expression of the p55 TNF soluble receptor (sTNFRs) by HSV-mediated gene transfer resulted in reduced pain behavior and a decreased number of ED1-positive cells, as well as decreased phosphorylation of the p38 MAP kinase (p-p38) and diminished expression of mTNF-alpha in the dorsal horn.
Phosphorylation (phosphorylation) of mTNF-alpha in dorsal horn
9) Confidence 0.55 Published 2006 Journal Ann. Neurol. Section Body Doc Link 16634039 Disease Relevance 0.13 Pain Relevance 0
The results suggest that in the brain the form of TNF alpha detectable by standard procedures is the cell bound form and not the most common form, secreted TNF alpha.
Phosphorylation (form) of TNF alpha in brain
10) Confidence 0.45 Published 1990 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 2378485 Disease Relevance 0.15 Pain Relevance 0.41
We have demonstrated that tactile allodynia and spontaneous pain of female rats with tibia tumors were correlated with the increase of both phosphorylated-p38MAPK (p-p38MAPK) and proinflammatory cytokines (IL-1beta and TNF-alpha) in the spinal cord 6 days after Walker 256 cells' inoculation.
Phosphorylation (phosphorylated) of TNF-alpha in spinal cord associated with pain, brush evoked pain, cancer, spontaneous pain, spinal cord and cytokine
11) Confidence 0.37 Published 2010 Journal Brain Res. Section Abstract Doc Link 20478276 Disease Relevance 1.10 Pain Relevance 0.94
The contents of plasma amylase and endotoxin, serum NO, TNF-?
Phosphorylation (amylase) of TNF in plasma
12) Confidence 0.35 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2234334 Disease Relevance 0.54 Pain Relevance 0
On the other hand, a 3-day administration [4 microg/rat/day, intrathecally (i.t.)] of 4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole (SB203580), an inhibitor of p38MAPK, could suppress tactile allodynia and spontaneous pain of the bone cancer pain rats and decrease the phosphorylation of p38 as well as the expression of IL-1beta and TNF-alpha.
Phosphorylation (phosphorylation) of TNF-alpha associated with pain, brush evoked pain, cancer pain and spontaneous pain
13) Confidence 0.28 Published 2010 Journal Brain Res. Section Abstract Doc Link 20478276 Disease Relevance 1.30 Pain Relevance 1.08
Although IkappaB inhibitor suppressed the TNF-alpha-induced IL-6 release, the Rho-kinase inhibitors did not affect the TNF-alpha-induced IkappaB phosphorylation.
Phosphorylation (phosphorylation) of TNF-alpha
14) Confidence 0.20 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19427347 Disease Relevance 0.54 Pain Relevance 0.03
The Rho-kinase inhibitors attenuated the TNF-alpha-induced phosphorylation of both p38 MAP kinase and SAPK/JNK.
Phosphorylation (phosphorylation) of TNF-alpha
15) Confidence 0.20 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19427347 Disease Relevance 0.92 Pain Relevance 0.28

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