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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.65
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Acsl1) endoplasmic reticulum (Acsl1) plasma membrane (Acsl1)
peroxisome (Acsl1) ligase activity (Acsl1) lipid metabolic process (Acsl1)
Anatomy Link Frequency
Heart 1
Acsl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 28 100.00 Very High Very High Very High
behavioral therapy 4 94.56 High High
depression 111 93.08 High High
antidepressant 14 91.44 High High
sSRI 13 87.80 High High
tricyclic antidepressant 3 48.60 Quite Low
Nortriptyline 1 31.60 Quite Low
Endep 1 31.00 Quite Low
Serotonin 13 5.00 Very Low Very Low Very Low
Inflammation 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 123 100.00 Very High Very High Very High
Acute Coronary Syndrome 44 100.00 Very High Very High Very High
Coronary Artery Disease 25 97.36 Very High Very High Very High
Cognitive Disorder 2 94.96 High High
Myocardial Infarction 35 93.20 High High
Attention Deficit Hyperactivity Disorder 5 73.92 Quite High
Heart Rate Under Development 2 72.84 Quite High
Dizziness 2 72.32 Quite High
Akathisia 2 66.96 Quite High
Sleep Disorders 3 66.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further, the multicenter SADHART randomized controlled trial of 369 post-ACS patients with major depressive disorder (MDD) found sertraline to be safe, well-tolerated, and efficacious in patients who began treatment approximately 1 month post-ACS.10 Furthermore, a post hoc analysis of the Enhancing Recovery in Coronary Heart Disease Patients (ENRICHD) trial (a trial of cognitive behavioral therapy (CBT) for post-MI depression that had some patients taking antidepressants in both the experimental and control groups) found that patients receiving SSRIs had an over 40% reduction in the risk of cardiac mortality and reinfarction over a mean 29 month follow-up, compared to those not taking SSRIs.121 One potential mechanism by which SSRIs may reduce cardiac events may involve reduction of platelet activity, as treatment of depressed patients with SSRIs leads to decreased markers of platelet hyperactivity.65,122,123
Regulation (controlled) of ACS in Heart associated with coronary artery disease, depression, behavioral therapy, ischemia, antidepressant, cognitive disorder, ssri, attention deficit hyperactivity disorder and myocardial infarction
1) Confidence 0.03 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2874336 Disease Relevance 1.65 Pain Relevance 0.75
This may be due to known post-transcriptional regulation of ACS [66,67] or to the fact that ACO and ACS expression profiles frequently differ in timing [68-71].
Regulation (regulation) of ACS
2) Confidence 0.01 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2358903 Disease Relevance 0 Pain Relevance 0

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