INT23094

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Context Info
Confidence 0.49
First Reported 1985
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 29
Total Number 30
Disease Relevance 6.80
Pain Relevance 9.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ca2) extracellular space (Ca2) lyase activity (Ca2)
response to stress (Ca2) cytoplasm (Ca2)
Anatomy Link Frequency
neurons 6
astrocyte 4
cerebellar granule cells 2
sensory neurons 2
plasma 2
Ca2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
imagery 97 100.00 Very High Very High Very High
qutenza 117 99.98 Very High Very High Very High
Action potential 107 99.98 Very High Very High Very High
Glutamate 113 99.84 Very High Very High Very High
antagonist 118 99.52 Very High Very High Very High
long-term potentiation 167 99.42 Very High Very High Very High
nMDA receptor 81 99.20 Very High Very High Very High
Dopamine 23 98.96 Very High Very High Very High
Calcium channel 8 98.12 Very High Very High Very High
Glutamate receptor 22 97.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Amputation 31 100.00 Very High Very High Very High
Acidosis 141 99.98 Very High Very High Very High
Apoptosis 16 99.82 Very High Very High Very High
Stress 56 99.44 Very High Very High Very High
Nociception 44 98.80 Very High Very High Very High
Convulsion 148 98.16 Very High Very High Very High
Depression 29 97.44 Very High Very High Very High
Blister 2 95.52 Very High Very High Very High
Death 33 95.44 Very High Very High Very High
Wrinkles 2 90.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment with the calcium channel blockers nimodipine (1 mg/kg s.c.), diltiazem (10 mg/kg s.c.) and verapamil (2.5 mg/kg s.c.) potentiated the hypothermic effect of U-50,488H as well as the stimulation of Ca2+/Mg2+ ATPase in hypothalamus.
Positive_regulation (potentiated) of Positive_regulation (stimulation) of Ca2 in hypothalamus associated with calcium channel
1) Confidence 0.49 Published 1986 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3028838 Disease Relevance 0.07 Pain Relevance 0.42
We also compared the average number of spontaneous Ca2+ surges per astrocyte in the first and the last 10 min of the 30 min imaging session, revealing no significant difference (0.5±1.2 vs. 0.7±1.3, t-test, p?
Positive_regulation (surges) of Positive_regulation (spontaneous) of Ca2 in astrocyte associated with imagery
2) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424136 Disease Relevance 0.09 Pain Relevance 0.13
These findings indicate that increases in intracellular Ca2+ levels induced in glial cells by local glutamate application and by synaptic activity share similar mechanisms (activation of L-type Ca2+ channels and group I/II metabotropic glutamate receptors) but also have distinct components (NMDA vs. non-NMDA receptor activation, respectively).
Positive_regulation (induced) of Positive_regulation (increases) of Ca2 in glial cells associated with glutamate, nmda receptor and glutamate receptor
3) Confidence 0.41 Published 2001 Journal Hippocampus Section Abstract Doc Link 11345120 Disease Relevance 0 Pain Relevance 0.83
In isolated rat extensor digitorum longus (EDL) muscle mounted for isometric contractions, chronic low-frequency electrical stimulation was found to lead to an increased uptake of 45Ca (154% above control after 240 min) and a progressive accumulation of Ca2+ (85% above control after 240 min).
Positive_regulation (lead) of Positive_regulation (accumulation) of Ca2 in extensor digitorum longus
4) Confidence 0.40 Published 1999 Journal Am. J. Physiol. Section Abstract Doc Link 9950909 Disease Relevance 0 Pain Relevance 0
Maitotoxin (10 ng/ml) caused a remarkable increase of intrasynaptosomal Ca2+ levels monitored by the fluorescent probe fura-2.
Positive_regulation (caused) of Positive_regulation (increase) of Ca2
5) Confidence 0.39 Published 1990 Journal Biochim. Biophys. Acta Section Abstract Doc Link 2378876 Disease Relevance 0 Pain Relevance 0.09
This enhanced influx of Ca2+ causes an increase of intrasynaptosomal Ca2+ levels.
Positive_regulation (causes) of Positive_regulation (increase) of Ca2
6) Confidence 0.39 Published 1990 Journal Biochim. Biophys. Acta Section Abstract Doc Link 2378876 Disease Relevance 0 Pain Relevance 0
One possible explanation therefore is that intracellular acidosis causes a sustained increase in Ca2+ leak from the ER.
Positive_regulation (causes) of Positive_regulation (increase) of Ca2 associated with acidosis
7) Confidence 0.38 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765625 Disease Relevance 0.46 Pain Relevance 0.06
Both agents caused an elevation of cytosolic Ca2+, assessed by phosphorylase a activity, which was accompanied by the concomitant appearance of plasma membrane blebs.
Positive_regulation (caused) of Positive_regulation (elevation) of Ca2 in plasma associated with blister
8) Confidence 0.37 Published 1985 Journal J. Biol. Chem. Section Abstract Doc Link 2932433 Disease Relevance 0.25 Pain Relevance 0.16
Preliminary Ca2+ imaging experiments were also conducted to determine whether extracellular SCH-202676 (10 ?
Positive_regulation (conducted) of Positive_regulation (experiments) of Ca2 associated with imagery
9) Confidence 0.34 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC514605 Disease Relevance 0.05 Pain Relevance 0.94
Studies also shown that lens lipids have a high affinity to bind Ca2+ and any alteration may decrease its capacity, which results in elevated levels of Ca2+ [38,39].
Positive_regulation (results) of Positive_regulation (elevated) of Ca2 in lens
10) Confidence 0.31 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2779145 Disease Relevance 0.16 Pain Relevance 0
In the absence of glutamate receptor block, the D1 antagonist SCH23390 (1 microM) reduced Ca2+ in responding cells; in contrast, the D2 antagonist eticlopride (1 microM) generated a delayed increase in Ca2+ levels. 7.
Positive_regulation (generated) of Positive_regulation (increase) of Ca2 associated with antagonist and glutamate receptor
11) Confidence 0.30 Published 1996 Journal J. Neurophysiol. Section Abstract Doc Link 8985891 Disease Relevance 0.07 Pain Relevance 1.25
These parameters are all relevant for activation of distinct Ca2+-dependent signal transduction pathways involving protein phosphatases and kinases.
Positive_regulation (relevant) of Positive_regulation (activation) of Ca2
12) Confidence 0.27 Published 2008 Journal Mol Pain Section Body Doc Link PMC2424039 Disease Relevance 0.73 Pain Relevance 0.94
CaMKII is activated by an increased [Ca2+]i and phosphorylates AMPA receptors, thereby increasing their channel conductance.
Positive_regulation (activated) of Positive_regulation (increased) of Ca2
13) Confidence 0.27 Published 2008 Journal Mol Pain Section Body Doc Link PMC2424039 Disease Relevance 0.35 Pain Relevance 0.47
These data suggest that Ca2+ flux through P- and/or Q-type VDCC subsequent to NMDA-induced depolarization may be at least as important for NOS activation as Ca2+ entry through the NMDA receptor.
Spec (may) Positive_regulation (important) of Positive_regulation (activation) of Ca2 associated with nmda receptor
14) Confidence 0.24 Published 1995 Journal Neuroreport Section Abstract Doc Link 8595213 Disease Relevance 0.08 Pain Relevance 0.26
Due to the lack of voltage-dependent Ca2+ channels in astrocytes, the Ca2+ elevation in these cells upon high K+ stimulation occurs with a delay of several seconds with respect to the response in neurons, and appears to be mediated by glutamate release from depolarizing neurons [17].
Positive_regulation (occurs) of Positive_regulation (elevation) of Ca2 in neurons associated with glutamate
15) Confidence 0.24 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2854117 Disease Relevance 0.08 Pain Relevance 0.26
Recent studies demonstrated that inhibition of NCX1 by substitution of Na+ with Li+ and Cs+ affects NMDA-induced intracellular Ca2+ increase in glucose-deprived and depolarized cerebellar granule cells (Blaustein & Lederer, 1999; Kiedrowski 1999).
Positive_regulation (induced) of Positive_regulation (increase) of Ca2 in cerebellar granule cells
16) Confidence 0.22 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC3015038 Disease Relevance 0.38 Pain Relevance 0.32
LTP induction in the CA1 region requires Ca2+ influx through NMDAR, either through direct activation of Ca2+-sensitive substrates and/or subsequent Ca2+ release from intracellular Ca2+ stores [1,35].
Positive_regulation (requires) of Positive_regulation (activation) of Ca2 associated with long-term potentiation
17) Confidence 0.20 Published 2008 Journal Mol Brain Section Body Doc Link PMC2570668 Disease Relevance 0 Pain Relevance 0.47
The delay of each SIC activated in neurons after astrocyte stimulation with TFLLR was calculated with respect to the peak of the immediately preceding astrocyte Ca2+ increase.
Positive_regulation (calculated) of Positive_regulation (increase) of Ca2 in astrocyte
18) Confidence 0.18 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2854117 Disease Relevance 0.17 Pain Relevance 0.03
It is conceivable that membrane potential depolarization induced by amputation results in the enhancement of Ca2+ influx through voltage-dependent Ca2+ channels and NMDA receptors, which might initiate the intracellular events leading to the alteration of synaptic transmission.
Positive_regulation (induced) of Positive_regulation (enhancement) of Ca2 associated with nmda receptor and amputation
19) Confidence 0.16 Published 2005 Journal Mol Pain Section Body Doc Link PMC1198253 Disease Relevance 0.97 Pain Relevance 1.11
Due to the lack of voltage-dependent Ca2+ channels in astrocytes, the Ca2+ elevation in these cells upon high K+ stimulation occurs with a delay of several seconds with respect to the response in neurons, and appears to be mediated by glutamate release from depolarizing neurons [17].
Positive_regulation (mediated) of Positive_regulation (elevation) of Ca2 in neurons associated with glutamate
20) Confidence 0.16 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2854117 Disease Relevance 0.09 Pain Relevance 0.27

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