INT230954

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Context Info
Confidence 0.39
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 4.54
Pain Relevance 1.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (RUNX2) nucleus (RUNX2) DNA binding (RUNX2)
Anatomy Link Frequency
osteoblast 1
extracellular matrix 1
RUNX2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 18 98.40 Very High Very High Very High
Osteoarthritis 309 98.16 Very High Very High Very High
Inflammation 55 97.20 Very High Very High Very High
cytokine 26 96.68 Very High Very High Very High
Arthritis 24 79.60 Quite High
rheumatoid arthritis 12 62.16 Quite High
Inflammatory stimuli 3 33.52 Quite Low
Neurotransmitter 6 29.44 Quite Low
bDMF 1 8.40 Low Low
agonist 36 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 19 99.54 Very High Very High Very High
Osteoarthritis 312 98.16 Very High Very High Very High
INFLAMMATION 54 97.20 Very High Very High Very High
Cancer 46 97.08 Very High Very High Very High
Osteogenic Sarcomas 79 96.80 Very High Very High Very High
Disease 19 86.96 High High
Sarcoma 2 86.56 High High
Obesity 20 85.36 High High
Arthritis 27 79.60 Quite High
Apoptosis 25 71.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Members of the MAP kinase family phosphorylate a number of transcription factors including runt-related transcription factor-2 (RUNX-2), with subsequent activation of matrix metalloproteinases (MMPs) and inflammatory cytokine gene expressions [3]. p38-MAPK, in particular, can regulate cytokine production through a variety of transcriptional and translational mechanisms [4].
Negative_regulation (number) of runt-related transcription factor-2 associated with inflammation, metalloproteinase and cytokine
1) Confidence 0.39 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.94 Pain Relevance 0.67
Members of the MAP kinase family phosphorylate a number of transcription factors including runt-related transcription factor-2 (RUNX-2), with subsequent activation of matrix metalloproteinases (MMPs) and inflammatory cytokine gene expressions [3]. p38-MAPK, in particular, can regulate cytokine production through a variety of transcriptional and translational mechanisms [4].
Negative_regulation (number) of RUNX-2 associated with inflammation, metalloproteinase and cytokine
2) Confidence 0.39 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.94 Pain Relevance 0.69
Thus, our results suggest that PE or PE-derived compounds may be useful in blocking the activation of MKK3 and might provide the benefit of p38-MAPK inhibition and its downstream targets such as RUNX-2 without the direct inhibition of p38-MAPK in OA.
Negative_regulation (inhibition) of RUNX-2 associated with osteoarthritis
3) Confidence 0.39 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.82 Pain Relevance 0.44
Rb coactivates the osteoblast differentiating agent Runx2 and loss of function of Rb stalls terminal osteoblast differentiation [139].
Negative_regulation (loss) of Runx2 in osteoblast associated with osteoporosis
4) Confidence 0.15 Published 2010 Journal PPAR Research Section Body Doc Link PMC2825651 Disease Relevance 1.31 Pain Relevance 0
Differentiated cells were not able to mineralize the matrix due to the important decreased of TUFT1, COL IV, V, XI, XII, OSF-2 and the modification of the extracellular matrix component after the differentiation (CSPG4, HAPLN1, ECM2, FN1).
Negative_regulation (decreased) of OSF-2 in extracellular matrix
5) Confidence 0.08 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2358905 Disease Relevance 0.54 Pain Relevance 0

General Comments

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