INT230965

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Context Info
Confidence 0.24
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.48
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neuronal 1
AREG (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 4 82.08 Quite High
agonist 29 38.56 Quite Low
pruritus 2 23.92 Low Low
Neurotransmitter 6 23.84 Low Low
Chronic pancreatitis 1 19.44 Low Low
Inflammation 37 5.00 Very Low Very Low Very Low
antagonist 13 5.00 Very Low Very Low Very Low
Glutamate 6 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
Glutamate receptor 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 28 98.48 Very High Very High Very High
Adenocarcinoma 17 98.16 Very High Very High Very High
Aggression 4 98.06 Very High Very High Very High
Cancer 117 97.44 Very High Very High Very High
Apoptosis 11 97.02 Very High Very High Very High
Chronic Obstructive Pulmonary Disease 2 91.36 High High
Toxicity 19 80.48 Quite High
Neurodegenerative Disease 9 80.04 Quite High
Acne 6 79.76 Quite High
Exanthema 13 78.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Amphiregulin is activated by metalloproteases and can be induced by cAMP activation, and increased levels of amphiregulin expression and release in airways, after activation by human airway trypsin-like protease through PAR2 receptor activation, result in mucus hypersecretion in chronic obstructive airway disease [46].
Positive_regulation (induced) of Amphiregulin associated with chronic obstructive pulmonary disease
1) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.56 Pain Relevance 0
Analysing these results, we observed that genes implicated in neuronal differentiation of neuronal precursors, including SOCS2, sFRP1, amphiregulin, neuronal growth regulator 1 and EphA4, were also upregulated after neurogenic differentiation of BM-MSC [33-35].
Positive_regulation (upregulated) of amphiregulin in neuronal
2) Confidence 0.24 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2358905 Disease Relevance 0.08 Pain Relevance 0
A recent report indicated that, in addition to K-RAS mutation being an indicator of resistance, high levels of the EGFR ligands epiregulin and amphiregulin correlated with response (Khambata-Ford 2007).
Positive_regulation (levels) of amphiregulin
3) Confidence 0.12 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721306 Disease Relevance 0.70 Pain Relevance 0
The notion that the activation of signal pathways associated with cell proliferation and resistance to apoptosis may, at least partially, explain the aggressiveness of pancreatic cancer which is supported by our findings that several mediators of such effects (amphiregulin, heparin-binding EGF like growth factor, epiregulin and vascular endothelial growth factor C) and their corresponding receptors were upregulated.
Positive_regulation (upregulated) of amphiregulin associated with pancreatic cancer, aggression and apoptosis
4) Confidence 0.10 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2927995 Disease Relevance 1.14 Pain Relevance 0.15

General Comments

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