INT230973

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.70
Pain Relevance 0.40

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mitochondrion (SLC25A12) small molecule metabolic process (SLC25A12) carbohydrate metabolic process (SLC25A12)
transmembrane transport (SLC25A12)
Anatomy Link Frequency
prefrontal 2
extracellular matrix 1
SLC25A12 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate receptor 15 92.44 High High
Glutamate 48 89.12 High High
Neuropeptide 1 73.20 Quite High
amygdala 116 40.48 Quite Low
agonist 7 38.32 Quite Low
antagonist 10 35.76 Quite Low
nMDA receptor 50 5.00 Very Low Very Low Very Low
long-term potentiation 28 5.00 Very Low Very Low Very Low
withdrawal 18 5.00 Very Low Very Low Very Low
Pyramidal cell 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autism 628 99.28 Very High Very High Very High
Neurodegenerative Disease 9 92.40 High High
Neurological Disease 2 64.16 Quite High
Adhesions 4 58.64 Quite High
Aging 3 10.12 Low Low
Anxiety Disorder 104 5.00 Very Low Very Low Very Low
Cognitive Disorder 86 5.00 Very Low Very Low Very Low
Intellectual Impairment 48 5.00 Very Low Very Low Very Low
Syndrome 42 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Even though larger follow up-studies were not able to confirm the association of SLC25A12 with autism (Blasi et al., 2006; Rabionet et al., 2006), two more recent studies again suggest a link between SLC25A12 and autism: one study reported an increase of SLC25A12 expression in prefrontal and cerebellar post-mortem tissue of autistic brains (Lepagnol-Bestel et al., 2008) and another study suggested a link between SLC25A12 expression and in behavioral routines in autism (Silverman et al., 2008).
Gene_expression (expression) of SLC25A12 in prefrontal associated with autism
1) Confidence 0.36 Published 2010 Journal Frontiers in Human Neuroscience Section Body Doc Link PMC3010743 Disease Relevance 0.74 Pain Relevance 0.14
Even though larger follow up-studies were not able to confirm the association of SLC25A12 with autism (Blasi et al., 2006; Rabionet et al., 2006), two more recent studies again suggest a link between SLC25A12 and autism: one study reported an increase of SLC25A12 expression in prefrontal and cerebellar post-mortem tissue of autistic brains (Lepagnol-Bestel et al., 2008) and another study suggested a link between SLC25A12 expression and in behavioral routines in autism (Silverman et al., 2008).
Gene_expression (expression) of SLC25A12 in prefrontal associated with autism
2) Confidence 0.36 Published 2010 Journal Frontiers in Human Neuroscience Section Body Doc Link PMC3010743 Disease Relevance 0.74 Pain Relevance 0.18
Among the 1943 genes differentially expressed, genes down-regulated are involved in osteogenesis, chondrogenesis, adipogenesis, myogenesis and extracellular matrix component (tuftelin, AGC1, FADS3, tropomyosin, fibronectin, ECM2, HAPLN1, vimentin).
Gene_expression (expressed) of AGC1 in extracellular matrix
3) Confidence 0.06 Published 2008 Journal BMC Genomics Section Abstract Doc Link PMC2358905 Disease Relevance 0.22 Pain Relevance 0.08

General Comments

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