INT231014

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 5.52
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (MC4R) signal transducer activity (MC4R)
MC4R (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 15 97.84 Very High Very High Very High
Inflammation 3 79.88 Quite High
Pain 3 67.76 Quite High
nud 3 60.24 Quite High
agonist 9 5.00 Very Low Very Low Very Low
melanocortin 1 receptor 4 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 3 99.96 Very High Very High Very High
Appetite Loss 186 99.46 Very High Very High Very High
Cancer 183 99.28 Very High Very High Very High
Obesity 22 99.28 Very High Very High Very High
Weight Loss 57 96.40 Very High Very High Very High
Anorexia 45 95.76 Very High Very High Very High
Cytomegalovirus Infection 3 93.28 High High
INFLAMMATION 3 79.88 Quite High
Contagious Ecthyma 6 78.32 Quite High
Pain 3 67.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A series of experiments demonstrated that cancer cachexia is ameliorated by central MC4R blockade in MC4R knock out mice or by peripheral administration of an antagonist (e.g. agouti-related protein – AGRP) in rats, mice and sheep [9-13].
Negative_regulation (blockade) of MC4R associated with targeted disruption, appetite loss, cancer and antagonist
1) Confidence 0.43 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2359760 Disease Relevance 1.98 Pain Relevance 0.23
A series of experiments demonstrated that cancer cachexia is ameliorated by central MC4R blockade in MC4R knock out mice or by peripheral administration of an antagonist (e.g. agouti-related protein – AGRP) in rats, mice and sheep [9-13].
Negative_regulation (blockade) of MC4R associated with targeted disruption, appetite loss, cancer and antagonist
2) Confidence 0.43 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2359760 Disease Relevance 1.98 Pain Relevance 0.23
We first cloned 1.3 kb of sequences located downstream of the MC4R stop codon including the 3?
Negative_regulation (downstream) of MC4R
3) Confidence 0.40 Published 2010 Journal EMBO J Section Body Doc Link PMC2876958 Disease Relevance 0.26 Pain Relevance 0
In humans, mutations that reduce the function of the MC4R result in severe obesity [16-18].
Negative_regulation (reduce) of MC4R associated with obesity
4) Confidence 0.38 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2359760 Disease Relevance 1.29 Pain Relevance 0.12

General Comments

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