INT231031

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.05
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Egf) vesicle-mediated transport (Sec22b) Golgi apparatus (Sec22b)
endoplasmic reticulum (Sec22b) plasma membrane (Egf)
Anatomy Link Frequency
brain 1
Egf (Rattus norvegicus)
Sec22b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 92 99.80 Very High Very High Very High
amygdala 68 91.24 High High
agonist 30 56.44 Quite High
antagonist 22 55.84 Quite High
Hippocampus 2 30.24 Quite Low
anesthesia 4 5.00 Very Low Very Low Very Low
Neurotransmitter 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aids-related Complex 14 54.08 Quite High
Decapitation 4 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While it is possible that D1-like receptor activity alters the activity of ERs within the same cell, it is also plausible that D1-like receptor activity may influence ER activity within other cells by altering the release of growth factors such as epidermal growth factor and insulin-like growth factor-1, which activate ERs in ligand-independent manner in vitro and within the adult female rat brain [40], [41], [43].
epidermal growth factor Positive_regulation (activate) of ERs in brain
1) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2359852 Disease Relevance 0 Pain Relevance 0.17
Factors other than DA, such as epidermal growth factor [40]–[42] and insulin-like growth factor-1 [41], [43]–[45], have been found to activate ERs both in vitro and in vivo.
epidermal growth factor Positive_regulation (activate) of ERs associated with dopamine
2) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2359852 Disease Relevance 0.05 Pain Relevance 0.59

General Comments

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