INT23104

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Context Info
Confidence 0.70
First Reported 1980
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 20
Total Number 22
Disease Relevance 10.35
Pain Relevance 8.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Cga)
Anatomy Link Frequency
LHA 4
LHA 1
blood 1
neurons 1
PVN 1
Cga (Mus musculus)
Pain Link Frequency Relevance Heat
headache 15 100.00 Very High Very High Very High
Thalamus 3 100.00 Very High Very High Very High
narcan 22 99.50 Very High Very High Very High
abdominal pain 3 99.38 Very High Very High Very High
analgesia 4 99.16 Very High Very High Very High
Pain 27 99.02 Very High Very High Very High
tetrodotoxin 2 98.76 Very High Very High Very High
opioid receptor 3 98.40 Very High Very High Very High
Catecholamine 4 98.04 Very High Very High Very High
Hippocampus 1 97.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Headache 12 100.00 Very High Very High Very High
Reprotox - General 1 102 99.80 Very High Very High Very High
Hemoperitoneum 1 99.50 Very High Very High Very High
Abdominal Pain 3 99.38 Very High Very High Very High
Cancer 89 99.36 Very High Very High Very High
Nociception 3 99.36 Very High Very High Very High
Pain 19 99.02 Very High Very High Very High
Systemic Lupus Erythematosus 11 98.92 Very High Very High Very High
Hepatomegaly 1 97.72 Very High Very High Very High
Solid Tumor 4 97.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Unilateral intratesticular injection of 10 micrograms naloxone led to a dose-dependent increase in the hCG-responsiveness without altering the slope of the hCG dose-response curve.
Positive_regulation (increase) of hCG associated with narcan
1) Confidence 0.70 Published 1993 Journal Biol. Reprod. Section Abstract Doc Link 8485243 Disease Relevance 0 Pain Relevance 0.42
Mecamylamine (1.0 mg/kg) reduced the duration but not the peak effect of stimulating the LHA.
Positive_regulation (stimulating) of LHA in LHA
2) Confidence 0.46 Published 1996 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 9196558 Disease Relevance 0.07 Pain Relevance 0.90
A 15-sec period of 35 microA sine-wave stimulation of the LHA significantly increased the latency of the tail reflex for periods up to 30 min.
Positive_regulation (stimulation) of LHA in LHA
3) Confidence 0.40 Published 1996 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 9196558 Disease Relevance 0.07 Pain Relevance 0.66
Pathologically, the tumor was a choriocarcinoma, and the HCG in the blood was slightly elevated.
Positive_regulation (elevated) of HCG in blood associated with cancer and reprotox - general 1
4) Confidence 0.40 Published 1990 Journal Gan No Rinsho Section Abstract Doc Link 2381047 Disease Relevance 0.81 Pain Relevance 0.10
New-onset or significant increase of severe and/or persistent headaches (LHA) were reported in 43% of the patients during a mean follow-up of 3.6 years.
Positive_regulation (increase) of LHA associated with headache
5) Confidence 0.40 Published 2003 Journal Lupus Section Abstract Doc Link 12945718 Disease Relevance 2.54 Pain Relevance 1.06
Serum HCG was elevated without pregnancy.
Positive_regulation (elevated) of HCG
6) Confidence 0.40 Published 2006 Journal J. Neurooncol. Section Abstract Doc Link 16132500 Disease Relevance 1.11 Pain Relevance 0.29
Occasionally HCG levels remain elevated more than 30 days postoperatively with eventual resolution; Cartwright et al (1986) claim that tubal patency rates appear to be unaffected by this prolonged clearance of tissue.
Positive_regulation (elevated) of HCG
7) Confidence 0.39 Published 1989 Journal Baillieres Clin Obstet Gynaecol Section Abstract Doc Link 2533012 Disease Relevance 0.82 Pain Relevance 0.15
During the years 1990-1993, 56 women were admitted into the Divisione di Ostetricia e Ginecologia of the Istituto per l'Infanzia of Trieste because of EP diagnosed on the basis of clinical history and signs, transvaginal echography and serum HCG levels. 33 of them underwent surgical operation for the presence of severe abdominal pain, hemoperitoneum greater than 50 cc, and increases HCG level.
Positive_regulation (increases) of HCG associated with reprotox - general 2, abdominal pain and hemoperitoneum
8) Confidence 0.39 Published 1995 Journal Minerva Ginecol Section Abstract Doc Link 8820395 Disease Relevance 0.60 Pain Relevance 0.10
The stimulation of LHA is known to produce analgesia of both tonic and phasic pain.
Positive_regulation (stimulation) of LHA in LHA associated with pain and analgesia
9) Confidence 0.37 Published 2001 Journal Neurobiology (Bp) Section Abstract Doc Link 11558930 Disease Relevance 0.45 Pain Relevance 0.40
The increase of c-Fos-positive cells number in 2 hours after LPS injection was observed in AFTN, PVH, LHA, VMH, DMH and PH.
Positive_regulation (increase) of LHA
10) Confidence 0.28 Published 2006 Journal Ross Fiziol Zh Im I M Sechenova Section Abstract Doc Link 17385422 Disease Relevance 0.50 Pain Relevance 0.28
Naltrexone injection into the rLHa increased neural activation in the LHa, indicating the presence of functional opioid receptors in this region.
Positive_regulation (increased) of LHa in LHa associated with opioid receptor
11) Confidence 0.15 Published 2006 Journal Brain Res. Section Abstract Doc Link 16716266 Disease Relevance 0 Pain Relevance 0.82
Moreover, both secretion of NSE (Fig. 6D, left panel) and CgA accumulation (Fig. 6D, right panel and Figure S1) were markedly diminished while Akt phosphorylation was unchanged hence suggesting that SphK1 inhibition can to a certain extent block the NE transdifferentiation.
Positive_regulation (accumulation) of CgA
12) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779655 Disease Relevance 0 Pain Relevance 0
The treatment with Fsk/IBMX or Epi strongly stimulated SphK1 activity (Fig. 7A), and correlated with increased cAMP content (Fig. 7B) and acquisition of NE morphology (data not shown) characterized biochemically by CgA accumulation (Fig. 7C).
Positive_regulation (accumulation) of CgA
13) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779655 Disease Relevance 0.05 Pain Relevance 0.05
Of note, the blockade of CgA accumulation induced by the PI3K inhibitors WT and LY294002 was markedly associated with a decrease in both Akt phosphorylation and SphK1 activity (Fig. 6C, right panel and Figure S1).
Positive_regulation (accumulation) of CgA
14) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779655 Disease Relevance 0 Pain Relevance 0
Immunoreactive glucagon (IRG) and insulin (IRI), glucose, catecholamines, and beta-endorphin were monitored in portal and peripheral plasma, before and during electrical stimulation of the LHA.
Positive_regulation (stimulation) of LHA in LHA associated with catecholamine
15) Confidence 0.13 Published 1983 Journal Endocrinology Section Abstract Doc Link 6305629 Disease Relevance 0 Pain Relevance 0.32
After electrical pain stimulation, the number of c-Fos-positive cells increased in these same hypothalamic structures (AHN, PVH, LHA, VMH, DMH, and PH).
Positive_regulation (increased) of LHA associated with pain
16) Confidence 0.12 Published 2008 Journal Neurosci. Behav. Physiol. Section Abstract Doc Link 18197387 Disease Relevance 0.64 Pain Relevance 0.43
A 28-year-old businessman presented with abdominal pain and masses associated with an elevated HCG level for which he underwent exploratory laparotomy.
Positive_regulation (elevated) of HCG associated with abdominal pain
17) Confidence 0.08 Published 1986 Journal Gan To Kagaku Ryoho Section Abstract Doc Link 2427033 Disease Relevance 0.41 Pain Relevance 0.16
A 33-year-old woman presented with severe abdominal acites and effusion after ovarian stimulation with HMG followed by ovulation induction with HCG.
Positive_regulation (induction) of HCG
18) Confidence 0.08 Published 2009 Journal Masui Section Abstract Doc Link 19306640 Disease Relevance 0.77 Pain Relevance 0.21
Serum levels of CEA and serum and urine levels of beta-HCG were markedly elevated.
Positive_regulation (elevated) of HCG in urine
19) Confidence 0.06 Published 1980 Journal Am. J. Gastroenterol. Section Abstract Doc Link 6990747 Disease Relevance 0.46 Pain Relevance 0.10
Electrolytic lesion and stimulation of the arcuate nucleus of the hypothalamus (ARH) were investigated in Wistar albino rats. 1) Discrete lesion of the ARH is followed by hyperalgesia as manifested by significantly high values of pain rating in the formalin test and by depressed analgesic effect of electroacupuncture stimulation on digastric electromyogram (dEMG) activity. 2) ARH stimulation appreciably suppressed both the responses of neurons in the lateral hypothalamus (LHA) and dEMG activity induced by tooth pulp stimulation.
Positive_regulation (induced) of LHA in neurons associated with pain, hyperalgesia, analgesic and electroacupuncture
20) Confidence 0.04 Published 1988 Journal Brain Res. Bull. Section Abstract Doc Link 3219607 Disease Relevance 0.26 Pain Relevance 0.61

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