INT231094

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Context Info
Confidence 0.07
First Reported 2008
Last Reported 2009
Negated 1
Speculated 1
Reported most in Body
Documents 5
Total Number 9
Disease Relevance 1.73
Pain Relevance 1.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA binding (Luc7l3) mRNA processing (Luc7l3) plasma membrane (Luc7l3)
nucleus (Luc7l3) DNA binding (Luc7l3) response to stress (Luc7l3)
Anatomy Link Frequency
myoblasts 2
Luc7l3 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 300 99.92 Very High Very High Very High
GABAergic 52 99.58 Very High Very High Very High
gABA 516 97.88 Very High Very High Very High
Neurotransmitter 92 97.04 Very High Very High Very High
antagonist 112 94.40 High High
GABA receptor 36 88.56 High High
agonist 112 57.28 Quite High
tetrodotoxin 88 39.56 Quite Low
Action potential 68 37.68 Quite Low
dopamine receptor 16 29.68 Quite Low
Disease Link Frequency Relevance Heat
Aids-related Complex 320 99.44 Very High Very High Very High
Targeted Disruption 13 62.60 Quite High
Ganglion Cysts 104 33.60 Quite Low
Frailty 19 5.00 Very Low Very Low Very Low
Appetite Loss 14 5.00 Very Low Very Low Very Low
Dislocations 13 5.00 Very Low Very Low Very Low
Stress 12 5.00 Very Low Very Low Very Low
Camurati-engelmann Disease 8 5.00 Very Low Very Low Very Low
Decapitation 8 5.00 Very Low Very Low Very Low
Body Weight 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The first peak of PER2::LUC expression occurred at hour 14.81 ± 0.29 of projected Zeitgeber time (ZT; i.e., 2.81 h after the time of lights off in the mouse colony; mean ± standard error of the mean [SEM]; n = 11).
Positive_regulation (occurred) of Gene_expression (expression) of LUC
1) Confidence 0.07 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.05
M; n = 4; Figure 4H), indicating that GABAergic transmission is not required for retinal PER2::LUC rhythms generation.
Neg (not) Positive_regulation (required) of Gene_expression (generation) of LUC associated with gabaergic
2) Confidence 0.06 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.67
PER2::LUC rhythms persisted during depletion of retinal dopamine by 100 ?
Positive_regulation (persisted) of Gene_expression (rhythms) of LUC associated with dopamine
3) Confidence 0.06 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0.06 Pain Relevance 0.44
We first examined whether dopamine is required for retinal PER2::LUC rhythms generation.
Spec (whether) Positive_regulation (required) of Gene_expression (generation) of LUC associated with dopamine
4) Confidence 0.06 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0.06 Pain Relevance 0.43
The average period of the oscillations from rhythmic slices was 22.3 ± 0.5 h and peak PER2::LUC expression was observed 30.4 ± 1.3 h after cull (Fig. 2, Table 1).
Positive_regulation (peak) of Gene_expression (expression) of LUC
5) Confidence 0.05 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0.18 Pain Relevance 0
For comparison with the above recordings of bioluminescence rhythms in MBH nuclei, we also assessed circadian variation of PER2::LUC expression in the SCN.
Positive_regulation (variation) of Gene_expression (expression) of LUC
6) Confidence 0.05 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0.14 Pain Relevance 0
The average period of the oscillations from all slices was 23.3 ± 0.4 h and peak PER2::LUC expression was observed 31.3 ± 0.9 h after cull (Table 1).


Positive_regulation (peak) of Gene_expression (expression) of LUC
7) Confidence 0.05 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0.05 Pain Relevance 0
Peak PER2::LUC expression in the whole Arc was observed 28.6 ± 0.3 h after cull.
Positive_regulation (Peak) of Gene_expression (expression) of LUC associated with aids-related complex
8) Confidence 0.05 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 1.24 Pain Relevance 0
For transfection of pARE-Luc, C2C12 myoblasts were transfected with 0.5 µg with Lipofectamine 2000 according the manufacturer's instructions.
Positive_regulation (transfected) of Gene_expression (transfection) of pARE-Luc in myoblasts
9) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2361191 Disease Relevance 0 Pain Relevance 0

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