INT231129

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Context Info
Confidence 0.30
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.73
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (HAND1) nucleolus (HAND1) nucleus (HAND1)
enzyme binding (HAND1) transcription factor binding (HAND1) cytoplasm (HAND1)
Anatomy Link Frequency
finger 3
ANS 1
HAND1 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 44 93.60 High High
Angina 1 90.96 High High
Electroencephalography 51 90.40 High High
Catecholamine 2 74.88 Quite High
Central nervous system 35 60.64 Quite High
magnetoencephalography 18 5.00 Very Low Very Low Very Low
Inflammation 14 5.00 Very Low Very Low Very Low
Multiple sclerosis 11 5.00 Very Low Very Low Very Low
chemokine 9 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 166 98.84 Very High Very High Very High
Neurological Disease 19 97.32 Very High Very High Very High
Coronary Artery Disease 79 96.88 Very High Very High Very High
Depression 52 93.60 High High
Cv General 3 Under Development 2 90.96 High High
Myocardial Infarction 4 89.56 High High
Leukocytosis 3 87.80 High High
Cardiovascular Disease 2 83.04 Quite High
Death 2 58.64 Quite High
Infection 46 56.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
5°) and mean luminance 3.7 cd/m2, which was presented as a baseline condition (Baseline); 2) watching a video of a manipulating androgynous hand (Hand); 3) watching a video of a manipulating male hand (Male); 4) watching a video of a manipulating female hand (Female); 5) watching a video of a moving white dot (Dot); and 6) manipulating a white chessman from right hand palm to finger tips at a rate of approximately 1-Hz (Execution).
Positive_regulation (manipulating) of hand in finger
1) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2361218 Disease Relevance 0 Pain Relevance 0.04
5°) and mean luminance 3.7 cd/m2, which was presented as a baseline condition (Baseline); 2) watching a video of a manipulating androgynous hand (Hand); 3) watching a video of a manipulating male hand (Male); 4) watching a video of a manipulating female hand (Female); 5) watching a video of a moving white dot (Dot); and 6) manipulating a white chessman from right hand palm to finger tips at a rate of approximately 1-Hz (Execution).
Positive_regulation (watching) of Hand in finger
2) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2361218 Disease Relevance 0 Pain Relevance 0.05
5°) and mean luminance 3.7 cd/m2, which was presented as a baseline condition (Baseline); 2) watching a video of a manipulating androgynous hand (Hand); 3) watching a video of a manipulating male hand (Male); 4) watching a video of a manipulating female hand (Female); 5) watching a video of a moving white dot (Dot); and 6) manipulating a white chessman from right hand palm to finger tips at a rate of approximately 1-Hz (Execution).
Positive_regulation (watching) of hand in finger
3) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2361218 Disease Relevance 0 Pain Relevance 0.05
However, three lines of evidence suggest that altered autonomic nervous system (ANS) activity in depressed patients might be responsible for the increased risk of mortality and medical morbidities in patients with CHD.
Spec (might) Positive_regulation (responsible) of autonomic nervous system in ANS associated with coronary artery disease
4) Confidence 0.06 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2882369 Disease Relevance 1.37 Pain Relevance 0.29
Post hoc analyses showed significantly higher MOG-IgG OD values in HAND and HIVOI patients compared to HIVasy (p < 0.05 and p < 0.01) and OND (both p < 0.001) patients.
Positive_regulation (values) of HAND associated with neurological disease
5) Confidence 0.05 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2998475 Disease Relevance 0.81 Pain Relevance 0.03
Furthermore, HIV neuroinvasion and BBB likely will provide future therapeutic targets for coping with the anticipated increase in HAND prevalence as more and more HIV patients come of age.


Positive_regulation (increase) of HAND associated with acquired immune deficiency syndrome or hiv infection
6) Confidence 0.01 Published 2010 Journal Retrovirology Section Body Doc Link PMC2864195 Disease Relevance 0.54 Pain Relevance 0

General Comments

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