INT231152

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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.64
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Dmd) cytoskeleton (Dmd) nucleus (Dmd)
cytoplasm (Dmd)
Anatomy Link Frequency
quadriceps 1
hearts 1
Dmd (Mus musculus)
Pain Link Frequency Relevance Heat
Neurotransmitter 44 83.36 Quite High
Hippocampus 24 76.24 Quite High
Central nervous system 17 60.56 Quite High
Glutamate 6 55.16 Quite High
tetrodotoxin 22 51.84 Quite High
sodium channel 9 47.12 Quite Low
Inflammation 8 45.76 Quite Low
Action potential 1 40.48 Quite Low
Pyramidal cell 8 39.92 Quite Low
Inflammatory response 2 33.04 Quite Low
Disease Link Frequency Relevance Heat
Cytomegalovirus Infection 23 99.56 Very High Very High Very High
Muscular Dystrophy 186 98.96 Very High Very High Very High
Colorblindness 4 98.40 Very High Very High Very High
Intellectual Impairment 14 97.12 Very High Very High Very High
Cognitive Disorder 24 95.60 Very High Very High Very High
Death 15 95.08 Very High Very High Very High
Disease 34 88.36 High High
Respiratory Syncytial Virus 13 82.48 Quite High
Body Weight 41 81.88 Quite High
Disease Progression 7 64.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A subset of DMD patients with deletions downstream of exon 30, affecting the splicing and transcription of Dp260, exhibit a red–green color vision defect, while DMD patients, who have dystrophin mutations upstream of exon 30 (solely affecting Dp427) have seemingly normal color vision.
Regulation (affecting) of Dp427 associated with colorblindness and muscular dystrophy
1) Confidence 0.47 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2840664 Disease Relevance 0.53 Pain Relevance 0
Roles for Dystrophin in Behavior
Regulation (Roles) of Dystrophin
2) Confidence 0.40 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2840664 Disease Relevance 0.82 Pain Relevance 0.14
This increase in the Ca2+ concentration is not the only alteration in dystrophin-lacking cells.
Neg (not) Regulation (alteration) of dystrophin
3) Confidence 0.36 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0.40 Pain Relevance 0.05
Our data regarding prednisone are consistent with the reports beneficial effects on serum CK levels in mdx mice [16].
Regulation (effects) of mdx
4) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888587 Disease Relevance 0 Pain Relevance 0
Eleven month old control mdx hearts and quadriceps were probed for levels of activin IIB receptor.
Regulation (control) of mdx in quadriceps
5) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820101 Disease Relevance 0.06 Pain Relevance 0
Myostatin inhibition resulted in a significant decrease in serum CK levels in the mdx 4H group compared to age matched control mdx levels (Fig. 4B); however, serum CK levels in the mdx 11L and 11H groups did not differ from eleven month old control mdx levels.
Regulation (control) of mdx
6) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820101 Disease Relevance 0.38 Pain Relevance 0
DMD mutations are most often comprised of insertions and deletions that alter the dystrophin reading frame or encode premature stop codons [3].
Regulation (alter) of dystrophin associated with muscular dystrophy
7) Confidence 0.10 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2362111 Disease Relevance 0.57 Pain Relevance 0
Eleven month old control mdx hearts and quadriceps were probed for levels of activin IIB receptor.
Regulation (control) of mdx in hearts
8) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820101 Disease Relevance 0.06 Pain Relevance 0
C infected mdx3cv mice (Figure 3B,C).
Regulation (infected) of mdx3cv
9) Confidence 0.05 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2713732 Disease Relevance 0.82 Pain Relevance 0

General Comments

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