INT231153

Context Info Confidence 0.29 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.43 Pain Relevance 0

plasma membrane (Dmd) cytoskeleton (Dmd) nucleus (Dmd) cytoplasm (Dmd)

Anatomy Link Frequency cardiac muscle 2 Dmd (Mus musculus)

Pain Link Frequency Relevance Heat fibrosis 36 39.00 Calcium channel 2 24.12 Potency 3 9.16 imagery 8 5.00 Inflammation 4 5.00 cytokine 1 5.00 ketamine 1 5.00 anesthesia 1 5.00 Angina 1 5.00 tolerance 1 5.00

Disease Link Frequency Relevance Heat Cardiomyopathy 63 96.32 Muscular Dystrophy 155 93.12 Disease 4 79.12 Dilated Cardiomyopathy 18 45.92 Fibrosis 43 39.00 Necrosis 3 26.48 Death 12 7.36 Duchenne Muscular Dystrophy 20 5.00 Stress 8 5.00 Congenital Anomalies 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The relatively mild phenotype and near normal life span of the mdx mouse has prompted the generation of double mutants such as the mdx/utrophin and the mdx/MyoD mice, both of which have a far more severe skeletal and cardiac muscle phenotype to model the development of cardiomyopathy.

Positive_regulation (generation) of Positive_regulation (/) of mdx in cardiac muscle associated with cardiomyopathy

1) Confidence 0.29 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC3024556 Disease Relevance 1.43 Pain Relevance 0

Western analysis showed that the highest level of dystrophin induction was achieved using 5 ?

Positive_regulation (achieved) of Positive_regulation (induction) of dystrophin

2) Confidence 0.19 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2362111 Disease Relevance 0 Pain Relevance 0

General Comments

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