INT231154

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Context Info
Confidence 0.07
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 2.18
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Aggf1) extracellular region (Aggf1) cell adhesion (Aggf1)
intracellular (Aggf1) cytoplasm (Aggf1)
Anatomy Link Frequency
poly 2
vessels 1
Aggf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 12 98.52 Very High Very High Very High
Analgesic 8 91.84 High High
Multiple sclerosis 16 85.20 High High
Spinal cord 4 59.68 Quite High
Inflammation 32 47.84 Quite Low
Taxol 12 41.32 Quite Low
imagery 110 5.00 Very Low Very Low Very Low
Inflammatory response 12 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 112 98.76 Very High Very High Very High
Skin Cancer 4 97.64 Very High Very High Very High
Carcinoma 4 97.40 Very High Very High Very High
Demyelinating Disease 16 85.20 High High
Multiple Sclerosis 4 79.60 Quite High
Muscular Dystrophy 15 77.88 Quite High
Lifespan 4 77.84 Quite High
Neurodegenerative Disease 12 75.76 Quite High
Disease 41 72.44 Quite High
Alzheimer's Dementia 4 70.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Polymeric micelles can be formed by copolymers of PEG and materials similar to PEG, such as poly(propylene oxide).
PEG Binding (copolymers) of in poly
1) Confidence 0.07 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2673971 Disease Relevance 0.25 Pain Relevance 0.24
Polymeric micelles can be formed by copolymers of PEG and materials similar to PEG, such as poly(propylene oxide).
PEG Binding (copolymers) of in poly
2) Confidence 0.07 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2673971 Disease Relevance 0.25 Pain Relevance 0.24
Surface coverage with PEG is also effective in these systems.
PEG Binding (coverage) of
3) Confidence 0.07 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2673971 Disease Relevance 0.43 Pain Relevance 0.33
When administered intravenously to mice with tumors induced by carcinoma or melanoma cells, the particles were readily taken up by the tumor, consistent with the increased residence time resulting from PEG conjugation (Harris and Chess 2003) and the known ‘leakiness’ of tumor vessels (also termed the enhanced permeability and retention, or EPR, effect; tumor vessels have 400–600 nm pores) (Yuan et al 1995).
PEG Binding (conjugation) of in vessels associated with cancer, carcinoma and skin cancer
4) Confidence 0.06 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2673971 Disease Relevance 1.09 Pain Relevance 0.04
We utilized a set of PEG-PEI copolymers containing 2 kDa PEI and either 550 Da or 5 kDa PEG, both of which bind 2'OMe ESOs with high affinity and form stable nanoparticulates with a relatively low surface charge.
PEG Binding (bind) of
5) Confidence 0.04 Published 2008 Journal BMC Biotechnol Section Abstract Doc Link PMC2362111 Disease Relevance 0.16 Pain Relevance 0

General Comments

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