INT23118

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Context Info
Confidence 0.30
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 1.74
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (AGL) transferase activity, transferring glycosyl groups (AGL) carbohydrate metabolic process (AGL)
cytoplasm (AGL) cytosol (AGL) hydrolase activity, acting on glycosyl bonds (AGL)
Anatomy Link Frequency
muscle fibers 6
enterocytes 2
hepatocytes 2
AGL (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 4 98.32 Very High Very High Very High
abdominal pain 1 67.20 Quite High
nud 1 63.36 Quite High
Paracetamol 1 58.12 Quite High
fibrosis 1 25.00 Low Low
addiction 24 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperglycemia 2 99.06 Very High Very High Very High
Obesity 16 97.02 Very High Very High Very High
Congenital Anomalies 3 92.00 High High
Hepatomegaly 6 91.28 High High
Diabetes Mellitus 7 90.72 High High
Hypoglycemia 4 84.40 Quite High
Glycogen Storage Disease 10 80.00 Quite High
Abdominal Pain 1 67.20 Quite High
Dyspepsia 1 63.36 Quite High
Vomiting 2 62.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Such schedules are designed to induce a ‘glycogen supercompensation’ effect, whereby glycogen depletion and carbohydrate restriction stimulate increased expression of glycogen synthase in the depleted muscle fibers, enhancing their ability to synthesize glycogen during the final, high-carbohydrate-diet phase, permitting muscle fibers to store glycogen in supranormal concentrations.
Positive_regulation (stimulate) of Gene_expression (expression) of glycogen in muscle fibers
1) Confidence 0.30 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2958805 Disease Relevance 0.06 Pain Relevance 0
This study demonstrates that in obese males physiological levels of FFA contribute to the retention of hepatic glycogen during short-term fasting by inhibiting breakdown of glycogen and increasing glycogen synthesis retained as glycogen, whereas in lean males this effect was absent due to unaltered glycogen synthesis retained as glycogen.
Positive_regulation (increasing) of Gene_expression (synthesis) of glycogen associated with obesity
2) Confidence 0.26 Published 2004 Journal Metab. Clin. Exp. Section Abstract Doc Link 15254882 Disease Relevance 0.31 Pain Relevance 0.06
Such schedules are designed to induce a ‘glycogen supercompensation’ effect, whereby glycogen depletion and carbohydrate restriction stimulate increased expression of glycogen synthase in the depleted muscle fibers, enhancing their ability to synthesize glycogen during the final, high-carbohydrate-diet phase, permitting muscle fibers to store glycogen in supranormal concentrations.
Positive_regulation (increased) of Gene_expression (expression) of glycogen in muscle fibers
3) Confidence 0.20 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2958805 Disease Relevance 0.06 Pain Relevance 0
Such schedules are designed to induce a ‘glycogen supercompensation’ effect, whereby glycogen depletion and carbohydrate restriction stimulate increased expression of glycogen synthase in the depleted muscle fibers, enhancing their ability to synthesize glycogen during the final, high-carbohydrate-diet phase, permitting muscle fibers to store glycogen in supranormal concentrations.
Positive_regulation (enhancing) of Gene_expression (synthesize) of glycogen in muscle fibers
4) Confidence 0.17 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2958805 Disease Relevance 0.07 Pain Relevance 0
In contrast, TTX itself, which causes maximal absorptive activity by blocking secretomotor neurons, induced the appearance of glycogen in the enterocytes without EFS.
Positive_regulation (induced) of Gene_expression (appearance) of glycogen in enterocytes associated with tetrodotoxin
5) Confidence 0.02 Published 1990 Journal Cell Tissue Res. Section Abstract Doc Link 2383885 Disease Relevance 0 Pain Relevance 0.39
During periods of hyperglycemia glucose freely enters the hepatocytes driving glycogen synthesis, which is augmented further by administration of insulin to supraphysiologic levels.
Positive_regulation (augmented) of Gene_expression (synthesis) of glycogen in hepatocytes associated with hyperglycemia
6) Confidence 0.00 Published 1996 Journal Medicine (Baltimore) Section Abstract Doc Link 8982149 Disease Relevance 1.24 Pain Relevance 0.10

General Comments

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