INT23122

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.72
First Reported 1980
Last Reported 2010
Negated 1
Speculated 4
Reported most in Abstract
Documents 31
Total Number 36
Disease Relevance 11.94
Pain Relevance 11.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ptger3) signal transducer activity (Ptger3)
Anatomy Link Frequency
uterine 5
PGE 2
neurons 2
macrophages 1
CSF 1
Ptger3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 52 100.00 Very High Very High Very High
acular 13 99.92 Very High Very High Very High
Paracetamol 33 99.84 Very High Very High Very High
cINOD 13 99.68 Very High Very High Very High
Central nervous system 12 99.68 Very High Very High Very High
Inflammation 53 99.40 Very High Very High Very High
Potency 1 99.24 Very High Very High Very High
Dismenorea 6 99.20 Very High Very High Very High
adenocard 2 99.00 Very High Very High Very High
nociceptor 20 98.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 7 100.00 Very High Very High Very High
Necrosis 4 100.00 Very High Very High Very High
Fever 12 99.88 Very High Very High Very High
INFLAMMATION 67 99.76 Very High Very High Very High
Hypothermia 20 99.48 Very High Very High Very High
Dysmenorrhea 6 99.20 Very High Very High Very High
Burns 1 99.04 Very High Very High Very High
Arthritis 2 98.96 Very High Very High Very High
Glioblastoma 3 98.56 Very High Very High Very High
Hyperalgesia 29 98.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results showed that EP2 and EP3 are expressed in trigeminal neurons (58% and 53% of total neurons, respectively) and are co-expressed in TRPV(1)-positive neurons (64% and 67 % of TRPV(1)-positive neurons, respectively).
Gene_expression (expressed) of EP3 in neurons
1) Confidence 0.72 Published 2008 Journal J. Dent. Res. Section Abstract Doc Link 18296611 Disease Relevance 0.15 Pain Relevance 0.55
We hypothesized that certain PGE(2) receptor subtypes (EP1-EP4) are co-expressed with TRPV(1) in trigeminal nociceptors and sensitize responses to a TRPV(1) agonist, capsaicin.
Gene_expression (expressed) of PGE in nociceptors associated with qutenza, nociceptor and agonist
2) Confidence 0.63 Published 2008 Journal J. Dent. Res. Section Abstract Doc Link 18296611 Disease Relevance 0.19 Pain Relevance 0.40
The results showed that EP2 and EP3 are expressed in trigeminal neurons (58% and 53% of total neurons, respectively) and are co-expressed in TRPV(1)-positive neurons (64% and 67 % of TRPV(1)-positive neurons, respectively).
Gene_expression (co-expressed) of EP3 in neurons
3) Confidence 0.62 Published 2008 Journal J. Dent. Res. Section Abstract Doc Link 18296611 Disease Relevance 0.15 Pain Relevance 0.56
Moreover, most of the cells expressing EP2 or EP3 mRNA were of small to medium diameter (< 30 microm).
Gene_expression (expressing) of EP3
4) Confidence 0.62 Published 2008 Journal J. Dent. Res. Section Abstract Doc Link 18296611 Disease Relevance 0.14 Pain Relevance 0.56
Only 3 and 6% of macrophages, respectively, expressed EP2 and EP3.
Gene_expression (expressed) of EP3 in macrophages
5) Confidence 0.54 Published 2003 Journal Exp. Neurol. Section Abstract Doc Link 14552899 Disease Relevance 0.31 Pain Relevance 0.48
Intraperitoneal injection of prostaglandin E1 (PGE) produces a transient hypothermia in rats that lasts 1-2 h.
Gene_expression (produces) of PGE in PGE associated with hypothermia
6) Confidence 0.46 Published 1990 Journal J. Appl. Physiol. Section Abstract Doc Link 2384439 Disease Relevance 0.43 Pain Relevance 0.07
At Ta of 4 degrees C, PGE produced a comparable fall in Tre of 1.00 +/- 0.14 degrees C.
Gene_expression (produced) of PGE in PGE
7) Confidence 0.46 Published 1990 Journal J. Appl. Physiol. Section Abstract Doc Link 2384439 Disease Relevance 0.58 Pain Relevance 0.18
PGE(2) and glutamate levels in CSF were analysed for 4 h.
Spec (analysed) Gene_expression (analysed) of PGE in CSF
8) Confidence 0.45 Published 2009 Journal Br J Anaesth Section Body Doc Link 19252201 Disease Relevance 0 Pain Relevance 0
The results show that rs7543182 and rs959 in PTGER3 retained their effect, although no statistical significance was retained in the 2(nd) cohort study.
Neg (no) Gene_expression (retained) of PTGER3
9) Confidence 0.44 Published 2010 Journal BMB Rep Section Abstract Doc Link 20587336 Disease Relevance 0.77 Pain Relevance 0.27
Among the positively associated SNPs, one in PTGER1 and four in PTGER3 were analyzed in the 2(nd) cohort study.
Spec (analyzed) Gene_expression (analyzed) of PTGER3
10) Confidence 0.39 Published 2010 Journal BMB Rep Section Abstract Doc Link 20587336 Disease Relevance 0.80 Pain Relevance 0.27
Blood samples were collected at various intervals after dosing to characterise naproxen pharmacokinetics and its effects on PGE(2) and TXB(2) production.
Gene_expression (production) of PGE in Blood
11) Confidence 0.38 Published 2010 Journal Eur J Pain Section Body Doc Link 19679500 Disease Relevance 0.09 Pain Relevance 0
In rats implanted with a femoral vein catheter and a cannula guide tube aimed towards the organum vasculosum laminae terminalis (OVLT) in the brain, an i.v. injection of 2 micrograms/kg interleukin-1 beta (IL-1 beta) produced a fever of 0.38 +/- 0.07 degrees C while an injection of 20 ng prostaglandin E1 (PGE) into the OVLT produced a fever of 1.18 +/- 0.18 degrees C.
Gene_expression (produced) of PGE in femoral vein associated with fever
12) Confidence 0.33 Published 1994 Journal Agents Actions Section Abstract Doc Link 7942328 Disease Relevance 0.86 Pain Relevance 0.35
We observed that on days 5 and 8 of psp, the L-NMMA (300 microM) treatment did not affect PGE production, but on day 9 of psp, the preincubation with the NOS inhibitor diminished PGE synthesis, suggesting that at this time endogenous NO can upregulate uterine PGE production.
Gene_expression (production) of PGE in uterine
13) Confidence 0.28 Published 1998 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 9690710 Disease Relevance 0 Pain Relevance 0.08
In summary, we suggest that in uterine tissue from psp rats, the NO system can alternatively decrease or increase uterine contractions, this last effect by enhancing uterine PGE synthesis.
Gene_expression (synthesis) of PGE in uterine associated with dismenorea
14) Confidence 0.28 Published 1998 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 9690710 Disease Relevance 0.10 Pain Relevance 0.10
These results confirm that NO can modulate uterine motility by means of PGE production.
Gene_expression (production) of PGE in uterine
15) Confidence 0.28 Published 1998 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 9690710 Disease Relevance 0 Pain Relevance 0.09
We observed that on days 5 and 8 of psp, the L-NMMA (300 microM) treatment did not affect PGE production, but on day 9 of psp, the preincubation with the NOS inhibitor diminished PGE synthesis, suggesting that at this time endogenous NO can upregulate uterine PGE production.
Gene_expression (synthesis) of PGE in uterine
16) Confidence 0.28 Published 1998 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 9690710 Disease Relevance 0 Pain Relevance 0.08
We observed that on days 5 and 8 of psp, the L-NMMA (300 microM) treatment did not affect PGE production, but on day 9 of psp, the preincubation with the NOS inhibitor diminished PGE synthesis, suggesting that at this time endogenous NO can upregulate uterine PGE production.
Gene_expression (production) of PGE in uterine
17) Confidence 0.28 Published 1998 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 9690710 Disease Relevance 0 Pain Relevance 0.07
Finally, we evaluated the relationship between endogenous NO and PGE production.
Gene_expression (production) of PGE
18) Confidence 0.28 Published 1998 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 9690710 Disease Relevance 0 Pain Relevance 0.06
Because no specific antagonists for EP2 and EP3 were readily available, agonists (butaporst for EP2 and sulprostone for EP3) were used.
Gene_expression (sulprostone) of EP3 associated with antagonist and agonist
19) Confidence 0.26 Published 2007 Journal Mol Pain Section Body Doc Link PMC2063498 Disease Relevance 0 Pain Relevance 0.34
In contrast, the EP3 agonist, sulprostone, at 0.1, 1, 10 ?
Gene_expression (agonist) of EP3 associated with agonist
20) Confidence 0.26 Published 2007 Journal Mol Pain Section Body Doc Link PMC2063498 Disease Relevance 0 Pain Relevance 0.35

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox