INT231256

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Context Info
Confidence 0.21
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.76
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Slc2a4) transport (Slc2a4) transmembrane transporter activity (Slc2a4)
plasma membrane (Slc2a4) transmembrane transport (Slc2a4) cytoplasm (Slc2a4)
Anatomy Link Frequency
cardiomyocytes 1
skeletal muscle cells 1
adipocytes 1
Slc2a4 (Mus musculus)
Pain Link Frequency Relevance Heat
excitatory amino acid 1 98.84 Very High Very High Very High
Glutamate 3 97.56 Very High Very High Very High
Calcium channel 1 95.80 Very High Very High Very High
Neurotransmitter 4 72.00 Quite High
Enkephalin 2 49.76 Quite Low
potassium channel 9 25.68 Quite Low
Hippocampus 7 10.56 Low Low
Nicotine 12 8.80 Low Low
antagonist 12 5.00 Very Low Very Low Very Low
imagery 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 11 98.86 Very High Very High Very High
Apoptosis 7 94.96 High High
Diabetes Mellitus 28 93.92 High High
Heart Disease 2 85.20 High High
Cognitive Disorder 62 50.00 Quite Low
Death 6 45.04 Quite Low
Coronary Heart Disease 4 32.72 Quite Low
Necrosis 1 8.08 Low Low
Cancer 2 7.72 Low Low
Leukemia 1 6.76 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Originally identified in adipocytes and skeletal muscle cells co-localised with the insulin-regulated glucose transporter GLUT4, it is also referred to as oxytocinase or placental leucine aminopeptidase.
Regulation (regulated) of GLUT4 in skeletal muscle cells associated with obesity
1) Confidence 0.21 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604899 Disease Relevance 0.10 Pain Relevance 0
Furthermore, our microarray analysis indicates that rosiglitazone did not upregulate important insulin-regulated glucose transporters such as Glut4 in the heart, a finding that has been reported previously in isolated rat cardiomyocytes [23].
Regulation (regulated) of Glut4 in cardiomyocytes
2) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481284 Disease Relevance 0.56 Pain Relevance 0
Originally identified in adipocytes and skeletal muscle cells co-localised with the insulin-regulated glucose transporter GLUT4, it is also referred to as oxytocinase or placental leucine aminopeptidase.
Regulation (regulated) of GLUT4 in adipocytes associated with obesity
3) Confidence 0.07 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604899 Disease Relevance 0.10 Pain Relevance 0
PtdIns 3K signaling regulates the trafficking of several cell surface proteins, such as glucose transporter 4 (Tengholm and Meyer, 2002), excitatory amino acid carrier 1 glutamate transporter (Davis et al., 1998), calcium channels (Viard et al., 2004), and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (Man et al., 2003).
Regulation (regulates) of glucose transporter 4 associated with glutamate, calcium channel and excitatory amino acid
4) Confidence 0.01 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0.18

General Comments

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