INT23126

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.60
First Reported 1990
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 5.42
Pain Relevance 4.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (HTR3A) plasma membrane (HTR3A) transmembrane transport (HTR3A)
Anatomy Link Frequency
neuronal 2
ileum 1
HTR3A (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 63 100.00 Very High Very High Very High
agonist 23 100.00 Very High Very High Very High
tramadol 13 100.00 Very High Very High Very High
corticosteroid 2 99.30 Very High Very High Very High
Paracetamol 1 99.24 Very High Very High Very High
Fibrositis 4 98.64 Very High Very High Very High
Migraine 1 98.52 Very High Very High Very High
nud 6 98.22 Very High Very High Very High
Pain threshold 3 98.08 Very High Very High Very High
rheumatoid arthritis 1 97.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatic Diseases 1 98.88 Very High Very High Very High
Fibromyalgia 2 98.64 Very High Very High Very High
Headache 3 98.52 Very High Very High Very High
Dyspepsia 6 98.22 Very High Very High Very High
Pain 6 98.08 Very High Very High Very High
Sleep Disorders 2 98.00 Very High Very High Very High
Rheumatoid Arthritis 1 97.80 Very High Very High Very High
Vomiting 120 97.60 Very High Very High Very High
Syndrome 4 97.60 Very High Very High Very High
INFLAMMATION 5 96.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results showed that EA improved the pain threshold of CVH rats, reduced the 5-HT concentration and increased the 5-HT4R concentration, but had no effect on the 5-HT3R concentration.
Neg (no) Regulation (effect) of 5-HT3R associated with pain threshold, nud and acupuncture
1) Confidence 0.60 Published 2009 Journal Neurochem. Res. Section Abstract Doc Link 19387829 Disease Relevance 0.65 Pain Relevance 0.86
Furthermore, very recent data from our lab indicate that the 5-HT3 antagonists, tropisetron, ondansetron and dolansetron, significantly reduce PGE2 release and 8-isoprostane formation (a reliable marker of free radical generation) in neuronal cells exposed to IL-1?
Regulation (dolansetron) of 5-HT3 in neuronal associated with antagonist
2) Confidence 0.44 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2259310 Disease Relevance 0.29 Pain Relevance 0.41
Furthermore, very recent data from our lab indicate that the 5-HT3 antagonists, tropisetron, ondansetron and dolansetron, significantly reduce PGE2 release and 8-isoprostane formation (a reliable marker of free radical generation) in neuronal cells exposed to IL-1?
Regulation (ondansetron) of 5-HT3 in neuronal associated with antagonist
3) Confidence 0.44 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2259310 Disease Relevance 0.29 Pain Relevance 0.41
Over the last three decades numerous antiemetic medications have been studied, including droperidol, metoclopramide, dimenhydrinate, promethazine, prochlorperazine, scopolamine, and corticosteroids but the greatest success has been documented with 5-HT3 receptor antagonists, in general, and ondansetron, in particular.
Regulation (documented) of 5-HT3 associated with corticosteroid, antagonist and vomiting
4) Confidence 0.44 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936315 Disease Relevance 1.10 Pain Relevance 0.10
The effects of 5-hydroxytryptamine (5-HT), the 5-HT1-like receptor agonist 5-carboxamidotryptamine and the 5-HT3 receptor agonist 2-methyl-5-hydroxytryptamine were studied on circular muscle strips of the canine terminal ileum and ileocolonic junction.
Regulation (effects) of 5-HT3 in ileum associated with agonist
5) Confidence 0.44 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2384890 Disease Relevance 0 Pain Relevance 0.19
Effects of tramadol and O-demethyl-tramadol on human 5-HT reuptake carriers and human 5-HT3A receptors: a possible mechanism for tramadol-induced early emesis.

([3H]5-HT)-uptake and patch-clamp techniques were used to study the actions of (+) and (-) tramadol and the active metabolites of tramadol, (+) and (-) O-demethyl-tramadol on the human serotonin (5-HT) transporter and the human 5-HT3A receptor, stably expressed in HEK-293 cells.

Regulation (Effects) of 5-HT3A associated with tramadol, vomiting and serotonin
6) Confidence 0.44 Published 2006 Journal Eur. J. Pharmacol. Section Title Doc Link 16427041 Disease Relevance 0.10 Pain Relevance 0.91
Most recent data also suggest that 5-HT3 receptor antagonists are effective for the treatment of other rheumatic diseases such as rheumatoid arthritis, tendinopathies, periarthropathies, and myofascial pain.
Regulation (effective) of 5-HT3 associated with snapping jaw, antagonist, rheumatoid arthritis, tendinopathy and rheumatic diseases
7) Confidence 0.44 Published 2004 Journal Scand. J. Rheumatol. Suppl. Section Abstract Doc Link 15515404 Disease Relevance 1.88 Pain Relevance 1.09
Effects of metformin on intestinal 5-hydroxytryptamine (5-HT) release and on 5-HT3 receptors.
Regulation (Effects) of 5-HT3
8) Confidence 0.44 Published 2000 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 10651152 Disease Relevance 0.28 Pain Relevance 0.30
7 nAChRs or via direct antagonist effects on 5-HT3 receptors.
Regulation (effects) of 5-HT3 associated with antagonist
9) Confidence 0.44 Published 2010 Journal Ann Gen Psychiatry Section Body Doc Link PMC2901366 Disease Relevance 0.42 Pain Relevance 0.26
OBJECTIVE: To study the efficacy of 5-hydroxytryptamine type 3 receptor (5-HT-3R) antagonist (ondansetron) vs paracetamol in primary fibromyalgia (FM) syndrome.
Regulation (efficacy) of 5-HT-3R associated with paracetamol, syndrome, antagonist and fibrositis
10) Confidence 0.26 Published 1996 Journal J. Rheumatol. Section Abstract Doc Link 8856622 Disease Relevance 0.27 Pain Relevance 0.27

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox