INT231264

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Context Info
Confidence 0.35
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 1.45
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Erbb3) extracellular space (Erbb3) nucleus (Erbb3)
kinase activity (Erbb3)
Anatomy Link Frequency
radial 3
Erbb3 (Mus musculus)
Pain Link Frequency Relevance Heat
positron emission tomography 51 95.36 Very High Very High Very High
Neurotransmitter 4 78.64 Quite High
interneuron 6 54.32 Quite High
imagery 51 50.00 Quite Low
gABA 18 15.52 Low Low
excitatory amino acid 1 11.92 Low Low
Glutamate 3 9.36 Low Low
antagonist 14 8.64 Low Low
Calcium channel 1 5.84 Low Low
cerebral cortex 30 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 194 93.76 High High
Hyperplasia 1 90.00 High High
Breast Cancer 12 87.04 High High
Glioblastoma 14 85.52 High High
Leukemia 1 79.48 Quite High
Carcinoma 8 71.32 Quite High
Prostate Cancer 4 68.20 Quite High
Severe Combined Immunodeficiency 2 60.44 Quite High
Stomach Cancer 1 58.32 Quite High
Adhesions 22 53.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
S4, available at http://www.jcb.org/cgi/content/full/jcb.200710037/DC1), by the ErbB3 present on glia, or after depolarization (Bao et al., 2003, 2004), locally regulates the levels of presynaptic ?
Gene_expression (present) of ErbB3
1) Confidence 0.35 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0.04
4 can regulate the expression of ErBB-3 at the level of protein translation, resulting in a significant induction of ErBB-2/ErBB-3 heterodimerization and consequent activation of PI3K (Folgiero et al. 2007; Liu et al. 2007).
Gene_expression (expression) of ErBB-3
2) Confidence 0.17 Published 2008 Journal Perspectives in Medicinal Chemistry Section Body Doc Link PMC2746574 Disease Relevance 0.84 Pain Relevance 0
This is consistent with previous reports showing that erbB3 and erbB4 are expressed by radial glia [23] and mediate radial glial elongation [23], [63], [28].
Gene_expression (expressed) of erbB3 in radial
3) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0.03
Surface expression of HER-2 proteins was almost negative on both cell lines, while HER-3 was expressed only in the U138MG cell line.
Gene_expression (expressed) of HER-3
4) Confidence 0.14 Published 2010 Journal Mol Imaging Biol Section Body Doc Link PMC2978890 Disease Relevance 0.37 Pain Relevance 0.04
Indirect immunofluorescence and cytofluorometric analyses were used to study the growth factor receptor expression profile of EGFR (HER-1) and HER/erbB family receptors HER-2 and HER-3 in U138MG and U87MG cells.
Gene_expression (expression) of HER-3
5) Confidence 0.14 Published 2010 Journal Mol Imaging Biol Section Body Doc Link PMC2978890 Disease Relevance 0.25 Pain Relevance 0.05
We also show that the effect mediated by NRG1 is erbB3/erbB4 and Pi3K-dependent.
Gene_expression (is) of erbB3
6) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0
Together, these results indicate that NRG1 via activation of erbB3/erbB4 receptors and Pi3K induces a realignment of vimentin+ radial glia (see also Figure 8).


Gene_expression (receptors) of erbB3 in radial
7) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0
Blockade of erbB3/erbB4 or inhibition of Pi3K signaling prevents the realignment of radial glia induced by NRG1
Gene_expression (/) of erbB3 in radial
8) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0
We also show that the effect mediated by NRG1 is erbB3/erbB4 and Pi3K-dependent.
Gene_expression (/) of erbB3
9) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0
Increased expression of BLBP in the presence of NRG1 is erbB3/4 and Pi3K dependent
Gene_expression (/) of erbB3
10) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0

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